@article{1f6e0d9f59604d80af6cda40e318a7ed,
title = "Development of Concurrent Retinotopic Maps in the Fly Motion Detection Circuit",
abstract = "Understanding how complex brain wiring is produced during development is a daunting challenge. In Drosophila, information from 800 retinal ommatidia is processed in distinct brain neuropiles, each subdivided into 800 matching retinotopic columns. The lobula plate comprises four T4 and four T5 neuronal subtypes. T4 neurons respond to bright edge motion, whereas T5 neurons respond to dark edge motion. Each is tuned to motion in one of the four cardinal directions, effectively establishing eight concurrent retinotopic maps to support wide-field motion. We discovered a mode of neurogenesis where two sequential Notch-dependent divisions of either a horizontal or a vertical progenitor produce matching sets of two T4 and two T5 neurons retinotopically coincident with pairwise opposite direction selectivity. We show that retinotopy is an emergent characteristic of this neurogenic program and derives directly from neuronal birth order. Our work illustrates how simple developmental rules can implement complex neural organization. The circuit for motion perception emerges out of the developmental program that specifies the identity of neurons.",
keywords = "Drosophila, Notch, direction selective neurons, neural connectivity, neural development, optic lobe, pattern formation, retinotopy",
author = "Filipe Pinto-Teixeira and Clara Koo and Rossi, {Anthony Michael} and Nathalie Neriec and Claire Bertet and Xin Li and Alberto Del-Valle-Rodriguez and Claude Desplan",
note = "Funding Information: We would like to dedicate this manuscript to the memory of Jean-Philippe Grossier with whom we had extensive discussions on the establishment of retinotopy. We would like to acknowledge Laura Quintana-Rio for help in building the 3D model of the developing optic lobe; Chris Doe and Cheng-Yu Lee for sharing reagents and suggestions for improving the antibody staining protocol; and Sarah Bennert for help with the elaboration of the illustrations. We also thank the fly community, especially the Doe lab and Janelia for gifts of antibodies and fly stocks and the Desplan laboratory members for essential discussion and support. This work was supported by the Center for Genomics and Systems Biology of NYU Abu Dhabi and an NIH grant ( R01 EY017916 to C.D.). F.P.-T., N.N., and A.D.-V.-R. were supported by the CGSB at NYUAD , and C.B. was supported by fellowships from EMBO ( ALTF 680-2009 ) and HFSPO ( LT000077/2010-L ). Funding Information: We would like to dedicate this manuscript to the memory of Jean-Philippe Grossier with whom we had extensive discussions on the establishment of retinotopy. We would like to acknowledge Laura Quintana-Rio for help in building the 3D model of the developing optic lobe; Chris Doe and Cheng-Yu Lee for sharing reagents and suggestions for improving the antibody staining protocol; and Sarah Bennert for help with the elaboration of the illustrations. We also thank the fly community, especially the Doe lab and Janelia for gifts of antibodies and fly stocks and the Desplan laboratory members for essential discussion and support. This work was supported by the Center for Genomics and Systems Biology of NYU Abu Dhabi and an NIH grant (R01 EY017916 to C.D.). F.P.-T., N.N., and A.D.-V.-R. were supported by the CGSB at NYUAD, and C.B. was supported by fellowships from EMBO (ALTF 680-2009) and HFSPO (LT000077/2010-L). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = apr,
day = "5",
doi = "10.1016/j.cell.2018.02.053",
language = "English (US)",
volume = "173",
pages = "485--498.e11",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}