Development of glycine receptor distribution in the lateral superior olive of the gerbil

D. H. Sanes, G. F. Wooten

Research output: Contribution to journalArticle

Abstract

The concentration and relative distribution of glycine receptors were determined for the gerbil lateral superior olive at several postnatal stages. Quantitative autoradiographic techniques revealed significant 3H-strychnine binding to all regions of the nucleus from 4 to 90 d. However, during the first 20 d, a nonuniform distribution of binding emerged, such that the greatest concentration of receptor was found in the high-frequency region of the nucleus. An analysis of neuron packing density showed an approximate 2-fold distribution along the same axis at all ages. This evidence is consistent with an elimination of glycine receptors in the ventral region of the lateral superior olive as maturation progresses.

Original languageEnglish (US)
Pages (from-to)3803-3811
Number of pages9
JournalJournal of Neuroscience
Volume7
Issue number11
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Neuroscience(all)

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