Development of reactions of silacyclopropanes as new methods for stereoselective organic synthesis

In this Account, we describe the development of stereospecific, stereoselective, regioselective, and chemoselective carbon-carbon bond-forming reactions of silacyclopropanes that occur under mild conditions. By appropriate choice of metal salt catalyst, the regiochemistry of these reactions may be tuned to give the desired product. Stereoselective nucleophilic substitution reactions and stereospecific oxidation of the C-Si bond to a carbon-oxygen bond demonstrate that the products of these reactions serve as useful intermediates for the synthesis of polyoxygenated organic molecules.