TY - GEN
T1 - Development of semi-chronic microdrive system for large-scale circuit mapping in macaque mesolimbic and basal ganglia systems
AU - Qiao, Shaoyu
AU - Brown, Kevin A.
AU - Orsborn, Amy L.
AU - Ferrentino, Breonna
AU - Pesaran, Bijan
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - The development of novel neurotechnologies for treating refractory neuropsychiatry disorders depends on understanding and manipulating the dynamics of neural circuits across large-scale brain networks. The mesolimbic pathway plays an essential role in reward processing and mood regulation and disorders of this pathway underlie many neuropsychiatric disorders. Here, we present the design of a customized semi-chronic microdrive array that precisely targets the anatomical structures of non-human primate (NHP) mesolimbic and basal ganglia systems. We present an integrated experimental paradigm that uses this device to map and manipulate large-scale neural circuits. The system combines electrophysiology, spatiotemporal multisite patterned intracortical microstimulation (ICMS), and diffusion tractography. We propose that this system provides a flexible platform for exploring and identifying neural signatures which can serve as novel targets for closed-loop stimulation in the clinical treatment of neuropsychiatric disorders.
AB - The development of novel neurotechnologies for treating refractory neuropsychiatry disorders depends on understanding and manipulating the dynamics of neural circuits across large-scale brain networks. The mesolimbic pathway plays an essential role in reward processing and mood regulation and disorders of this pathway underlie many neuropsychiatric disorders. Here, we present the design of a customized semi-chronic microdrive array that precisely targets the anatomical structures of non-human primate (NHP) mesolimbic and basal ganglia systems. We present an integrated experimental paradigm that uses this device to map and manipulate large-scale neural circuits. The system combines electrophysiology, spatiotemporal multisite patterned intracortical microstimulation (ICMS), and diffusion tractography. We propose that this system provides a flexible platform for exploring and identifying neural signatures which can serve as novel targets for closed-loop stimulation in the clinical treatment of neuropsychiatric disorders.
UR - http://www.scopus.com/inward/record.url?scp=85009085061&partnerID=8YFLogxK
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U2 - 10.1109/EMBC.2016.7592052
DO - 10.1109/EMBC.2016.7592052
M3 - Conference contribution
C2 - 28269579
AN - SCOPUS:85009085061
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 5825
EP - 5828
BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Y2 - 16 August 2016 through 20 August 2016
ER -