Developmental plasticity of inhibitory circuitry

Sarah L. Pallas, Peter Wenner, Carlos Gonzalez-Islas, Michela Fagiolini, Khaleel A. Razak, Gunsoo Kim, Dan Sanes, Birgit Roerig

Research output: Contribution to journalArticlepeer-review


A growing body of evidence suggests that plasticity at GABAergic synapses is of critical importance during development and aging. A balance between excitation and inhibition maintains homeostasis at the neuronal and circuit levels, and inhibitory plasticity can function to drive a perturbed system toward homeostasis. Activity-dependent modification of inhibitory synaptic strength must be non-Hebbian, however, because the interaction between an inhibitory neuron and its target prevents them from firing together. Mechanisms that may underlie inhibitory plasticity will be discussed, including the possibility that it is limited to the early period when GABA/glycine release is excitatory (Ben-Ari, 2002) or that corelease of another substance alters synapses that produce inhibition (Gillespie et al., 2005). Alternatively, inhibitory synapses may decline in strength through long-term depression (Kotak et al., 2001; Chang et al., 2003), or an as-yet undiscovered mechanism may be responsible. Whatever the mechanism, it is clear that inhibitory plasticity plays an important role in activity-dependent modification of developing circuits.

Original languageEnglish (US)
Pages (from-to)10358-10361
Number of pages4
JournalJournal of Neuroscience
Issue number41
StatePublished - Oct 11 2006

ASJC Scopus subject areas

  • General Neuroscience


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