Dietary fats and age-related macular degeneration

Research output: Contribution to journalReview articlepeer-review


Amount and type of dietary fat may play a role in the pathogenesis of age-related macular degeneration (AMD) via 4 potential mechanisms: (1) atherosclerosis, (2) altering retinal integrity, (3) oxidative damage, and (4) inflammation. In this report, 11 epidemiologic studies are evaluated for evidence of associations between dietary fats and AMD. Taken together, the studies suggest a protective association of higher omega-3 polyunsaturated fats and fish intake with AMD. The relations of AMD with total and types of fat varied across populations and may reflect different patterns of fat intake. Practitioners should advise a low-fat, "heart-healthy" diet and encourage consumption of diets high in omega-3 polyunsaturated fats.

Original languageEnglish (US)
Pages (from-to)347-356
Number of pages10
JournalTopics in Clinical Nutrition
Issue number4
StatePublished - Oct 2008


  • Age-related macular degeneration
  • Monounsaturated fats
  • Omega-3 polyunsaturated fats
  • Polyunsaturated fats
  • Saturated fats
  • Total fats

ASJC Scopus subject areas

  • Nutrition and Dietetics


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