TY - JOUR
T1 - Differential effects on somatic and reflex development by chronic clomipramine treatment
AU - Lopes De Souza, Sandra
AU - Nogueira, Maria Inês
AU - De Jesus Deiró, Tereza Cristina Bomfim
AU - De Castro, Francisco MacHado Manhaes
AU - Da Silva, Cristiano Mendes
AU - Da Silva, Matilde Cesiana
AU - De Lira, Luciene Oliveira
AU - Azmitia, Efrain C.
AU - De Castro, Raul Manhaes
N1 - Funding Information:
This study had financial support of CAPES and psychiatry HC-USP and MH55250 (ECA).
PY - 2004/9/15
Y1 - 2004/9/15
N2 - The developmental effect of altered 5-HT and NE levels is a subject that requires more attention, especially when considering the increased demand for antidepressive dual reuptake inhibitors. Serotonin and norepinephrine are bioamines that differentially influence the nervous tissue growth. This study investigated the somatic maturation and the ontogeny of reflexes in neonate rats treated from the 1st to the 21st postnatal day (PND) with clomipramine (20 mg/kg sc, daily), a potent monoamine reuptake inhibitor. Indicators of both general body growth (body weight, axis of the head and body lengths) and physical maturation (ear unfolding, auditory conduit opening, eruption of the lower incisors and eye opening) were appraised. Ontogeny of motor and sensory reflexes (righting, free-fall righting - acceleration, negative geotaxis, cliff avoidance, auditory startle response and vibrissa placing) was also observed. The results demonstrated that chronic neonatal treatment with clomipramine alters the somatic growth. However, it did not interfere with the onset time of many physical features and reflexes. These results provide insights into the consequences of dual transmitter during early development.
AB - The developmental effect of altered 5-HT and NE levels is a subject that requires more attention, especially when considering the increased demand for antidepressive dual reuptake inhibitors. Serotonin and norepinephrine are bioamines that differentially influence the nervous tissue growth. This study investigated the somatic maturation and the ontogeny of reflexes in neonate rats treated from the 1st to the 21st postnatal day (PND) with clomipramine (20 mg/kg sc, daily), a potent monoamine reuptake inhibitor. Indicators of both general body growth (body weight, axis of the head and body lengths) and physical maturation (ear unfolding, auditory conduit opening, eruption of the lower incisors and eye opening) were appraised. Ontogeny of motor and sensory reflexes (righting, free-fall righting - acceleration, negative geotaxis, cliff avoidance, auditory startle response and vibrissa placing) was also observed. The results demonstrated that chronic neonatal treatment with clomipramine alters the somatic growth. However, it did not interfere with the onset time of many physical features and reflexes. These results provide insights into the consequences of dual transmitter during early development.
KW - Body growth
KW - Clomipramine
KW - Neonatal rat
KW - Noradrenaline
KW - Reflex ontogeny
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=3242766000&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3242766000&partnerID=8YFLogxK
U2 - 10.1016/j.physbeh.2004.04.007
DO - 10.1016/j.physbeh.2004.04.007
M3 - Article
C2 - 15276801
AN - SCOPUS:3242766000
SN - 0031-9384
VL - 82
SP - 375
EP - 379
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 2-3
ER -