Differential sensitivity to prevention programming: A dopaminergic polymorphism-enhanced prevention effect on protective parenting and adolescent substance use

Gene H. Brody, Yi fu Chen, Steven R.H. Beach, Steven M. Kogan, Tianyi Yu, Ralph J. DiClemente, Gina M. Wingood, Michael Windle, Robert A. Philibert

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of this study was to investigate a genetic moderation effect of dopamine receptor-4 gene (DRD4) alleles that have 7 or more repeats on the efficacy of a preventive intervention to deter rural African American adolescents' substance use. Methods: Adolescents (N = 502, M age = 16 years) were assigned randomly to the Strong African American Families-Teen (SAAF-T) program or to a control condition and were followed for 22 months. Adolescents provided data on substance use, and both adolescents and their primary caregivers provided data on intervention-targeted protective parenting practices. Results: Male adolescents who carried at least one allele of DRD4 with 7 or more repeats who were assigned to the control condition evinced more substance use across 22 months than did (a) carriers of at least one allele of DRD4 with 7 or more repeats who were assigned to SAAF-T or (b) adolescents assigned to either condition who carried two alleles of DRD4 with 6 or fewer repeats. These findings were mediated by DRD4 × SAAF-T interaction effects on increases in intervention-targeted protective parenting practices, a mediated moderation effect. Conclusions: The results imply that prevention effects on health-relevant outcomes for genetically susceptible individuals, such as carriers of at least one allele of DRD4 with 7 or more repeats, may be underestimated.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalHealth Psychology
Volume33
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • African american
  • Genetics
  • Intervention
  • Prevention
  • Substance use

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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