@article{ef11b4d6b2e24aca8dfde401b305f4fc,
title = "Diffuse optical tomography of the breast: A potential modifiable biomarker of breast cancer risk with neoadjuvant chemotherapy",
abstract = "The purpose of this study is to evaluate whether a diffuse optical tomography breast imaging system (DOTBIS) can provide a comparable optical-based image index of mammographic breast density, an established biomarker of breast cancer risk. Oxyhemoglobin concentration (ctO2Hb) measured by DOTBIS was collected from 40 patients with stage II-III breast cancer. The tumor-free contralateral breast was used for this evaluation. We observed a moderate positive correlation between the patient{\textquoteright}s mammogram density classification and ctO2Hb, rs = 0.486 (p = 0.001). In addition, significant reduction in ctO2Hb levels were noted during neoadjuvant chemotherapy treatment (p = 0.017). This observation indicates that ctO2Hb levels measured by DOTBIS could be a novel modifiable imaging biomarker of breast cancer risk and warrants further investigation.",
author = "Altoe, {Mirella L.} and Alessandro Marone and Kim, {Hyun K.} and Kevin Kalinsky and Hershman, {Dawn L.} and Hielscher, {Andreas H.} and Ha, {Richard S.}",
note = "Funding Information: This work was supported in part by a grant from Columbia|Biomedx - Biomedical Technology Accelerator, the Breast Cancer Research Foundation, and National Institutes of Health (grant 11223309). Furthermore, Mirella L. Alto{\'e} was supported in part by a fellowship from CNPq/LASPAU – Brazil [207913/2014-5] and Alessandro Marone was supported in part by a Personalized Medicine Fellowship of the Irving Institute for Clinical and Translational Research at Columbia University in the City of New York. Funding Information: Breast Cancer Research Foundation; National Institutes of Health (grant 11223309).. This work was supported in part by a grant from Columbia|Biomedx-Biomedical Technology Accelerator, the Breast Cancer Research Foundation, and National Institutes of Health (grant 11223309). Furthermore, Mirella L. Alto{\'e} was supported in part by a fellowship from CNPq/LASPAU – Brazil [207913/2014-5] and Alessandro Marone was supported in part by a Personalized Medicine Fellowship of the Irving Institute for Clinical and Translational Research at Columbia University in the City of New York. Funding Information: Breast Cancer Research Foundation; National Institutes of Health (grant 11223309). Publisher Copyright: {\textcopyright} 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.",
year = "2019",
month = aug,
day = "1",
doi = "10.1364/BOE.10.004305",
language = "English (US)",
volume = "10",
pages = "4305--4315",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "8",
}