Diffusion Kurtosis Imaging Reveals Optic Tract Damage That Correlates with Clinical Severity in Glaucoma

Zhe Sun, Carlos Parra, Ji Won Bang, Els Fieremans, Gadi Wollstein, Joel S. Schuman, Kevin C. Chan

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Glaucoma is a neurodegenerative disease of the visual system and is the leading cause of irreversible blindness worldwide. To date, its pathophysiological mechanisms remain unclear. This study evaluated the feasibility of advanced diffusion magnetic resonance imaging techniques for examining the microstructural environment of the visual pathway in glaucoma. While conventional diffusion tensor imaging (DTI) showed lower fractional anisotropy and higher directional diffusivities in the optic tracts of glaucoma patients than healthy controls, diffusion kurtosis imaging (DKI) and the extended white matter tract integrity (WMTI) model indicated lower radial kurtosis, higher axial and radial diffusivities in the extra-axonal space, lower axonal water fraction, and lower tortuosity in the same regions in glaucoma patients. These findings suggest glial involvements apart from compromised axonal integrity in glaucoma. In addition, DKI and WMTI but not DTI parameters significantly correlated with clinical ophthalmic measures via optical coherence tomography and visual field perimetry testing. Taken together, DKI and WMTI provided sensitive and comprehensive imaging biomarkers for quantifying glaucomatous damage in the white matter tract across clinical severity complementary to DTI.

    Original languageEnglish (US)
    Title of host publication42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
    Subtitle of host publicationEnabling Innovative Technologies for Global Healthcare, EMBC 2020
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages1746-1749
    Number of pages4
    ISBN (Electronic)9781728119908
    DOIs
    StatePublished - Jul 2020
    Event42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada
    Duration: Jul 20 2020Jul 24 2020

    Publication series

    NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
    Volume2020-July
    ISSN (Print)1557-170X

    Conference

    Conference42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
    CountryCanada
    CityMontreal
    Period7/20/207/24/20

    ASJC Scopus subject areas

    • Signal Processing
    • Biomedical Engineering
    • Computer Vision and Pattern Recognition
    • Health Informatics

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  • Cite this

    Sun, Z., Parra, C., Bang, J. W., Fieremans, E., Wollstein, G., Schuman, J. S., & Chan, K. C. (2020). Diffusion Kurtosis Imaging Reveals Optic Tract Damage That Correlates with Clinical Severity in Glaucoma. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020 (pp. 1746-1749). [9176192] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC44109.2020.9176192