Digital analysis of protein properties by an ensemble of DNA quadruplexes

David Margulies, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review


(Figure Presented) Here we show how different principles developed in the area of molecular logic gates can be applied to diagnostic technologies for proteins. Simultaneous operation of YES NOT and PASS 1 logic gates, produced by a protein sensing ensemble of DNA G-quadruplexes, is used to encode concentration levels of medicinally important proteins. An AND logic gate is another example, where molecular computation can be used to follow the interaction between proteins and metal ions. Combination of molecular Boolean logic with combinatorial sensing is demonstrated as a general strategy to realizing small scale, real time diagnosis of a variety of protein samples.

Original languageEnglish (US)
Pages (from-to)9142-9143
Number of pages2
JournalJournal of the American Chemical Society
Issue number26
StatePublished - Jul 8 2009

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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