Abstract
Diffuse optical tomography has shown promising results as a tool for breast cancer screening and
monitoring response to chemotherapy. Dynamic imaging of the transient response of the breast to an external
stimulus, such as pressure or a respiratory maneuver, can provide additional information that can be used to detect
tumors. We present a new digital continuous-wave optical tomography system designed to simultaneously image
both breasts at fast frame rates and with a large number of sources and detectors. The system uses a master-slave
digital signal processor-based detection architecture to achieve a dynamic range of 160 dB and a frame rate
of 1.7 Hz with 32 sources, 64 detectors, and 4 wavelengths per breast. Included is a preliminary study of one
healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the
hemodynamic response to a breath hold.
monitoring response to chemotherapy. Dynamic imaging of the transient response of the breast to an external
stimulus, such as pressure or a respiratory maneuver, can provide additional information that can be used to detect
tumors. We present a new digital continuous-wave optical tomography system designed to simultaneously image
both breasts at fast frame rates and with a large number of sources and detectors. The system uses a master-slave
digital signal processor-based detection architecture to achieve a dynamic range of 160 dB and a frame rate
of 1.7 Hz with 32 sources, 64 detectors, and 4 wavelengths per breast. Included is a preliminary study of one
healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the
hemodynamic response to a breath hold.
| Original language | English (US) |
|---|---|
| Journal | Journal of Biomedical Optics |
| DOIs | |
| State | Published - 2011 |