Digital optical tomography system for dynamic breast imaging

Molly L. Flexman, Michael A. Khalil, Rabah Al Abdi, Hyun K Kim, Christopher J. Fong, Elise Desperito, Dawn L. Hershman, Randall L. Barbour, Andreas Hielscher

Research output: Contribution to journalArticlepeer-review


Diffuse optical tomography has shown promising results as a tool for breast cancer screening and
monitoring response to chemotherapy. Dynamic imaging of the transient response of the breast to an external
stimulus, such as pressure or a respiratory maneuver, can provide additional information that can be used to detect
tumors. We present a new digital continuous-wave optical tomography system designed to simultaneously image
both breasts at fast frame rates and with a large number of sources and detectors. The system uses a master-slave
digital signal processor-based detection architecture to achieve a dynamic range of 160 dB and a frame rate
of 1.7 Hz with 32 sources, 64 detectors, and 4 wavelengths per breast. Included is a preliminary study of one
healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the
hemodynamic response to a breath hold.
Original languageEnglish (US)
JournalJournal of Biomedical Optics
StatePublished - 2011


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