The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry