Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix

In Chul Kim; Andrew D. Hamilton

doi:10.1021/ol052956q

Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix

In Chul Kim, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.

Original language	English (US)
Pages (from-to)	1751-1754
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	9
DOIs	https://doi.org/10.1021/ol052956q
State	Published - Apr 27 2006

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol052956q

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Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix

Abstract

ASJC Scopus subject areas

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