Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an α-helix

In Chul Kim, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6- disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an α-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.

Original languageEnglish (US)
Pages (from-to)1751-1754
Number of pages4
JournalOrganic Letters
Volume8
Issue number9
DOIs
StatePublished - Apr 27 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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