TY - JOUR
T1 - Directional coupling of slow and fast hippocampal gamma with neocortical alpha/beta oscillations in human episodic memory
AU - Griffiths, Benjamin J.
AU - Parish, George
AU - Roux, Frederic
AU - Michelmann, Sebastian
AU - van der Plas, Mircea
AU - Kolibius, Luca D.
AU - Chelvarajah, Ramesh
AU - Rollings, David T.
AU - Sawlani, Vijay
AU - Hamer, Hajo
AU - Gollwitzer, Stephanie
AU - Kreiselmeyer, Gernot
AU - Staresina, Bernhard
AU - Wimber, Maria
AU - Hanslmayr, Simon
N1 - Publisher Copyright:
© 2019 National Academy of Sciences. All rights reserved.
PY - 2019/10/22
Y1 - 2019/10/22
N2 - Episodic memories hinge upon our ability to process a wide range of multisensory information and bind this information into a coherent, memorable representation. On a neural level, these 2 processes are thought to be supported by neocortical alpha/beta desynchronization and hippocampal theta/gamma synchronization, respectively. Intuitively, these 2 processes should couple to successfully create and retrieve episodic memories, yet this hypothesis has not been tested empirically. We address this by analyzing human intracranial electroencephalogram data recorded during 2 associative memory tasks. We find that neocortical alpha/beta (8 to 20 Hz) power decreases reliably precede and predict hippocampal “fast” gamma (60 to 80 Hz) power increases during episodic memory formation; during episodic memory retrieval, however, hippocampal “slow” gamma (40 to 50 Hz) power increases reliably precede and predict later neocortical alpha/beta power decreases. We speculate that this coupling reflects the flow of information from the neocortex to the hippocampus during memory formation, and hippocampal pattern completion inducing information reinstatement in the neocortex during memory retrieval.
AB - Episodic memories hinge upon our ability to process a wide range of multisensory information and bind this information into a coherent, memorable representation. On a neural level, these 2 processes are thought to be supported by neocortical alpha/beta desynchronization and hippocampal theta/gamma synchronization, respectively. Intuitively, these 2 processes should couple to successfully create and retrieve episodic memories, yet this hypothesis has not been tested empirically. We address this by analyzing human intracranial electroencephalogram data recorded during 2 associative memory tasks. We find that neocortical alpha/beta (8 to 20 Hz) power decreases reliably precede and predict hippocampal “fast” gamma (60 to 80 Hz) power increases during episodic memory formation; during episodic memory retrieval, however, hippocampal “slow” gamma (40 to 50 Hz) power increases reliably precede and predict later neocortical alpha/beta power decreases. We speculate that this coupling reflects the flow of information from the neocortex to the hippocampus during memory formation, and hippocampal pattern completion inducing information reinstatement in the neocortex during memory retrieval.
KW - Episodic memory
KW - Hippocampus
KW - Human
KW - Intracranial EEG
KW - Neural oscillations
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U2 - 10.1073/pnas.1914180116
DO - 10.1073/pnas.1914180116
M3 - Article
C2 - 31597741
AN - SCOPUS:85073732562
SN - 0027-8424
VL - 116
SP - 21834
EP - 21842
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 43
ER -