Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold

Lun K. Tsou, Ginger E. Dutschman, Elizabeth A. Gullen, Maria Telpoukhovskaia, Yung Chi Cheng, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.

Original languageEnglish (US)
Pages (from-to)2137-2139
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number7
DOIs
StatePublished - Apr 1 2010

Keywords

  • Calixarenes
  • HIV-HCV coinfection inhibitors
  • Protein surface recognition

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold'. Together they form a unique fingerprint.

Cite this