Discovery of new polymorphs of the tuberculosis drug isoniazid

Keke Zhang, Noalle Fellah, Alexander G. Shtukenberg, Xiaoyan Fu, Chunhua Hu, Michael D. Ward

Research output: Contribution to journalArticle

Abstract

Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement. The two new forms are readily distinguished from the known form by optical microscopy, Raman spectroscopy and X-ray powder diffraction. A single crystal structure was obtained for one of the new polymorphs.

Original languageEnglish (US)
Pages (from-to)2705-2708
Number of pages4
JournalCrystEngComm
Volume22
Issue number16
DOIs
StatePublished - Apr 28 2020

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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  • Cite this

    Zhang, K., Fellah, N., Shtukenberg, A. G., Fu, X., Hu, C., & Ward, M. D. (2020). Discovery of new polymorphs of the tuberculosis drug isoniazid. CrystEngComm, 22(16), 2705-2708. https://doi.org/10.1039/d0ce00440e