Discovery of new polymorphs of the tuberculosis drug isoniazid

Keke Zhang; Noalle Fellah; Alexander G. Shtukenberg; Xiaoyan Fu; Chunhua Hu; Michael D. Ward

doi:10.1039/d0ce00440e

Discovery of new polymorphs of the tuberculosis drug isoniazid

Keke Zhang, Noalle Fellah, Alexander G. Shtukenberg, Xiaoyan Fu, Chunhua Hu, Michael D. Ward

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement. The two new forms are readily distinguished from the known form by optical microscopy, Raman spectroscopy and X-ray powder diffraction. A single crystal structure was obtained for one of the new polymorphs.

Original language	English (US)
Pages (from-to)	2705-2708
Number of pages	4
Journal	CrystEngComm
Volume	22
Issue number	16
DOIs	https://doi.org/10.1039/d0ce00440e
State	Published - Apr 28 2020

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1039/d0ce00440e

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abstract = "Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement. The two new forms are readily distinguished from the known form by optical microscopy, Raman spectroscopy and X-ray powder diffraction. A single crystal structure was obtained for one of the new polymorphs.",

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AU - Hu, Chunhua

AU - Ward, Michael D.

PY - 2020/4/28

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AB - Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement. The two new forms are readily distinguished from the known form by optical microscopy, Raman spectroscopy and X-ray powder diffraction. A single crystal structure was obtained for one of the new polymorphs.

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Discovery of new polymorphs of the tuberculosis drug isoniazid

Abstract

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