Discriminating the size and density of objects within tissue: Frequency-domain versus steady-state measurements

Steven L. Jacques, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Steady-state (SS) optical measurements are simpler and less expensive than frequency-domain (FD) measurements. So why bother with FD? This paper illustrates the advantage obtained by FD vs. SS, using computer simulated experiments. A single shperical object is placed in the center of our model for the human prostate. The object is given a range of sized and values for its incremental absorption ((Delta) (mu) a ) above the background medium (bloodless prostate), with the condition that the optical volume (equals object volume X (Delta) (mu) a ) remains constant. Simulations of SS measurements and FD measurements using a 3 GHz modulation frequency were conducted and two measurements simulated: the frequency difference ((Delta) P equals phase with object-phase without object) and the relative amplitude (A/A 0 equals amplitude with object/amplitude without object). The results show that A/A 0 at SS and 3 GHz are very similar in their response to the object size, and the (Delta) P at 3 GHz offered important additional information.

    Original languageEnglish (US)
    Title of host publicationOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media
    Subtitle of host publicationTheory, Human Studies, and Instrumentation
    EditorsBritton Chance, Robert R. Alfano
    PublisherSPIE
    Pages228-239
    Number of pages12
    ISBN (Electronic)9780819417367
    DOIs
    StatePublished - May 30 1995
    EventOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation - San Jose, United States
    Duration: Feb 1 1995Feb 28 1995

    Publication series

    NameProceedings of SPIE - The International Society for Optical Engineering
    Volume2389
    ISSN (Print)0277-786X
    ISSN (Electronic)1996-756X

    Other

    OtherOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
    CountryUnited States
    CitySan Jose
    Period2/1/952/28/95

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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