Discrimination between hard metals with soft ligand donor atoms: An on-fluorescence probe for manganese(II)

Jian Liang; James W. Canary

doi:10.1002/anie.201002853

Discrimination between hard metals with soft ligand donor atoms: An on-fluorescence probe for manganese(II)

Jian Liang, James W. Canary

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A backwards strategy for achieving Mn²⁺/Ca²⁺ selectivity was demonstrated: Instead of optimizing binding of Mn²⁺, the bapta ligand (upper structure in scheme) was modified by changing O to N donors to discourage association by unwanted competitor Ca²⁺. Attachment of a fluorophore gave a Mn²⁺- selective on-fluorescent probe for use in live cell imaging.

Original language	English (US)
Pages (from-to)	7710-7713
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	42
DOIs	https://doi.org/10.1002/anie.201002853
State	Published - Oct 11 2010

Keywords

Calcium
Cellular imaging
Coordination chemistry
Fluorescence
Manganese

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201002853

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title = "Discrimination between hard metals with soft ligand donor atoms: An on-fluorescence probe for manganese(II)",

abstract = "A backwards strategy for achieving Mn2+/Ca2+ selectivity was demonstrated: Instead of optimizing binding of Mn2+, the bapta ligand (upper structure in scheme) was modified by changing O to N donors to discourage association by unwanted competitor Ca2+. Attachment of a fluorophore gave a Mn2+- selective on-fluorescent probe for use in live cell imaging.",

keywords = "Calcium, Cellular imaging, Coordination chemistry, Fluorescence, Manganese",

author = "Jian Liang and Canary, {James W.}",

year = "2010",

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AU - Canary, James W.

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N2 - A backwards strategy for achieving Mn2+/Ca2+ selectivity was demonstrated: Instead of optimizing binding of Mn2+, the bapta ligand (upper structure in scheme) was modified by changing O to N donors to discourage association by unwanted competitor Ca2+. Attachment of a fluorophore gave a Mn2+- selective on-fluorescent probe for use in live cell imaging.

AB - A backwards strategy for achieving Mn2+/Ca2+ selectivity was demonstrated: Instead of optimizing binding of Mn2+, the bapta ligand (upper structure in scheme) was modified by changing O to N donors to discourage association by unwanted competitor Ca2+. Attachment of a fluorophore gave a Mn2+- selective on-fluorescent probe for use in live cell imaging.

KW - Calcium

KW - Cellular imaging

KW - Coordination chemistry

KW - Fluorescence

KW - Manganese

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Discrimination between hard metals with soft ligand donor atoms: An on-fluorescence probe for manganese(II)

Abstract

Keywords

ASJC Scopus subject areas

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