Disorders of glucose metabolism in the context of human immunodeficiency virus infection

Ruth Larson, Bernadette Capili, Margaret Eckert-Norton, Joseph P. Colagreco, Joyce K. Anastasi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To discuss the pathophysiology and the current treatment approaches for the dysregulation of glucose metabolism in the context of human immunodeficiency virus (HIV) infection. Data sources: Selected research, clinical studies, clinical guidelines, and review articles. Conclusions: In HIV infection, multiple factors are associated with the pathogenesis of glucose dysregulation. Studies suggest that protease inhibitors, a class of antiretroviral agent, as well as viral factors, lipodystrophy, hepatitis C infection, injection drug use, and second-generation antipsychotics have been implicated in the development of glucose disorders and diabetes. Current treatment recommendations are based on extrapolated data from non-HIV diabetic patients. More research is needed to establish the most appropriate management for the disorders of glucose metabolism in the context of HIV infection. Implications for practice: If left untreated, patients are at increased risk for cardiovascular disease and complications associated with untreated diabetes.

Original languageEnglish (US)
Pages (from-to)92-103
Number of pages12
JournalJournal of the American Academy of Nurse Practitioners
Volume18
Issue number3
DOIs
StatePublished - Mar 2006

Keywords

  • Glucose metabolism
  • HIV
  • Insulin resistance
  • Metabolic syndrome

ASJC Scopus subject areas

  • Nursing(all)

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