Disruption of protein–protein interactions: Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Yen Wei; George L. Mc Lendon; Andrew D. Hamilton; Martin A. Case; Cherie B. Purring; Qing Lin; Hyung Soon Park; Chang Sun Leec; Tianning Yua

doi:10.1039/b104142h

Disruption of protein–protein interactions: Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Yen Wei, George L. Mc Lendon, Andrew D. Hamilton, Martin A. Case, Cherie B. Purring, Qing Lin, Hyung Soon Park, Chang Sun Leec, Tianning Yua

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 ± 1) × 10⁸ M⁻¹, and to disrupt Cc:Apaf−1 complex, a key adduct in apoptosis.

Original language	English (US)
Pages (from-to)	1580-1581
Number of pages	2
Journal	Chemical Communications
Volume	1
Issue number	17
DOIs	https://doi.org/10.1039/b104142h
State	Published - 2001

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/b104142h

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abstract = "Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 ± 1) × 108 M−1, and to disrupt Cc:Apaf−1 complex, a key adduct in apoptosis.",

author = "Yen Wei and {Mc Lendon}, {George L.} and Hamilton, {Andrew D.} and Case, {Martin A.} and Purring, {Cherie B.} and Qing Lin and Park, {Hyung Soon} and Leec, {Chang Sun} and Tianning Yua",

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T2 - Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

AU - Wei, Yen

AU - Mc Lendon, George L.

AU - Hamilton, Andrew D.

AU - Case, Martin A.

AU - Purring, Cherie B.

AU - Lin, Qing

AU - Park, Hyung Soon

AU - Leec, Chang Sun

AU - Yua, Tianning

PY - 2001

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AB - Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 ± 1) × 108 M−1, and to disrupt Cc:Apaf−1 complex, a key adduct in apoptosis.

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Disruption of protein–protein interactions: Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Abstract

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