Disruption of protein–protein interactions: Design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Yen Wei, George L. Mc Lendon, Andrew D. Hamilton, Martin A. Case, Cherie B. Purring, Qing Lin, Hyung Soon Park, Chang Sun Leec, Tianning Yua

Research output: Contribution to journalArticle

Abstract

Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 ± 1) × 108 M−1, and to disrupt Cc:Apaf−1 complex, a key adduct in apoptosis.

Original languageEnglish (US)
Pages (from-to)1580-1581
Number of pages2
JournalChemical Communications
Volume1
Issue number17
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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