Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

Kevin Hadi; Xiaotong Yao; Julie M. Behr; Aditya Deshpande; Charalampos Xanthopoulakis; Huasong Tian; Sarah Kudman; Joel Rosiene; Madison Darmofal; Joseph DeRose; Rick Mortensen; Emily M. Adney; Alon Shaiber; Zoran Gajic; Michael Sigouros; Kenneth Eng; Jeremiah A. Wala; Kazimierz O. Wrzeszczyński; Kanika Arora; Minita Shah; Anne Katrin Emde; Vanessa Felice; Mayu O. Frank; Robert B. Darnell; Mahmoud Ghandi; Franklin Huang; Sally Dewhurst; John Maciejowski; Titia de Lange; Jeremy Setton; Nadeem Riaz; Jorge S. Reis-Filho; Simon Powell; David A. Knowles; Ed Reznik; Bud Mishra; Rameen Beroukhim; Michael C. Zody; Nicolas Robine; Kenji M. Oman; Carissa A. Sanchez; Mary K. Kuhner; Lucian P. Smith; Patricia C. Galipeau; Thomas G. Paulson; Brian J. Reid; Xiaohong Li; David Wilkes; Andrea Sboner; Juan Miguel Mosquera; Olivier Elemento; Marcin Imielinski

doi:10.1016/j.cell.2020.08.006

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

Kevin Hadi, Xiaotong Yao, Julie M. Behr, Aditya Deshpande, Charalampos Xanthopoulakis, Huasong Tian, Sarah Kudman, Joel Rosiene, Madison Darmofal, Joseph DeRose, Rick Mortensen, Emily M. Adney, Alon Shaiber, Zoran Gajic, Michael Sigouros, Kenneth Eng, Jeremiah A. Wala, Kazimierz O. Wrzeszczyński, Kanika Arora, Minita ShahAnne Katrin Emde, Vanessa Felice, Mayu O. Frank, Robert B. Darnell, Mahmoud Ghandi, Franklin Huang, Sally Dewhurst, John Maciejowski, Titia de Lange, Jeremy Setton, Nadeem Riaz, Jorge S. Reis-Filho, Simon Powell, David A. Knowles, Ed Reznik, Bud Mishra, Rameen Beroukhim, Michael C. Zody, Nicolas Robine, Kenji M. Oman, Carissa A. Sanchez, Mary K. Kuhner, Lucian P. Smith, Patricia C. Galipeau, Thomas G. Paulson, Brian J. Reid, Xiaohong Li, David Wilkes, Andrea Sboner, Juan Miguel Mosquera, Olivier Elemento, Marcin Imielinski

Computer Science

Research output: Contribution to journal › Article › peer-review

Abstract

A novel computational approach for inferring and classifying patterns in cancer genome graphs uncovers three classes of complex structural variation with distinct tumor type and genomic distributions.

Original language	English (US)
Pages (from-to)	197-210.e32
Journal	Cell
Volume	183
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2020.08.006
State	Published - Oct 1 2020

Keywords

aneuploidy
cancer evolution
cancer genomics
chromothripsis
fragile sites
genome graphs
mutational processes
phasing
structural variation
superenhancers

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2020.08.006

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Hadi, K., Yao, X., Behr, J. M., Deshpande, A., Xanthopoulakis, C., Tian, H., Kudman, S., Rosiene, J., Darmofal, M., DeRose, J., Mortensen, R., Adney, E. M., Shaiber, A., Gajic, Z., Sigouros, M., Eng, K., Wala, J. A., Wrzeszczyński, K. O., Arora, K., ... Imielinski, M. (2020). Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs. Cell, 183(1), 197-210.e32. https://doi.org/10.1016/j.cell.2020.08.006

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs. / Hadi, Kevin; Yao, Xiaotong; Behr, Julie M.; Deshpande, Aditya; Xanthopoulakis, Charalampos; Tian, Huasong; Kudman, Sarah; Rosiene, Joel; Darmofal, Madison; DeRose, Joseph; Mortensen, Rick; Adney, Emily M.; Shaiber, Alon; Gajic, Zoran; Sigouros, Michael; Eng, Kenneth; Wala, Jeremiah A.; Wrzeszczyński, Kazimierz O.; Arora, Kanika; Shah, Minita; Emde, Anne Katrin; Felice, Vanessa; Frank, Mayu O.; Darnell, Robert B.; Ghandi, Mahmoud; Huang, Franklin; Dewhurst, Sally; Maciejowski, John; de Lange, Titia; Setton, Jeremy; Riaz, Nadeem; Reis-Filho, Jorge S.; Powell, Simon; Knowles, David A.; Reznik, Ed; Mishra, Bud; Beroukhim, Rameen; Zody, Michael C.; Robine, Nicolas; Oman, Kenji M.; Sanchez, Carissa A.; Kuhner, Mary K.; Smith, Lucian P.; Galipeau, Patricia C.; Paulson, Thomas G.; Reid, Brian J.; Li, Xiaohong; Wilkes, David; Sboner, Andrea; Mosquera, Juan Miguel; Elemento, Olivier; Imielinski, Marcin.

In: Cell, Vol. 183, No. 1, 01.10.2020, p. 197-210.e32.

Research output: Contribution to journal › Article › peer-review

Hadi, K, Yao, X, Behr, JM, Deshpande, A, Xanthopoulakis, C, Tian, H, Kudman, S, Rosiene, J, Darmofal, M, DeRose, J, Mortensen, R, Adney, EM, Shaiber, A, Gajic, Z, Sigouros, M, Eng, K, Wala, JA, Wrzeszczyński, KO, Arora, K, Shah, M, Emde, AK, Felice, V, Frank, MO, Darnell, RB, Ghandi, M, Huang, F, Dewhurst, S, Maciejowski, J, de Lange, T, Setton, J, Riaz, N, Reis-Filho, JS, Powell, S, Knowles, DA, Reznik, E, Mishra, B, Beroukhim, R, Zody, MC, Robine, N, Oman, KM, Sanchez, CA, Kuhner, MK, Smith, LP, Galipeau, PC, Paulson, TG, Reid, BJ, Li, X, Wilkes, D, Sboner, A, Mosquera, JM, Elemento, O & Imielinski, M 2020, 'Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs', Cell, vol. 183, no. 1, pp. 197-210.e32. https://doi.org/10.1016/j.cell.2020.08.006

Hadi, Kevin ; Yao, Xiaotong ; Behr, Julie M. ; Deshpande, Aditya ; Xanthopoulakis, Charalampos ; Tian, Huasong ; Kudman, Sarah ; Rosiene, Joel ; Darmofal, Madison ; DeRose, Joseph ; Mortensen, Rick ; Adney, Emily M. ; Shaiber, Alon ; Gajic, Zoran ; Sigouros, Michael ; Eng, Kenneth ; Wala, Jeremiah A. ; Wrzeszczyński, Kazimierz O. ; Arora, Kanika ; Shah, Minita ; Emde, Anne Katrin ; Felice, Vanessa ; Frank, Mayu O. ; Darnell, Robert B. ; Ghandi, Mahmoud ; Huang, Franklin ; Dewhurst, Sally ; Maciejowski, John ; de Lange, Titia ; Setton, Jeremy ; Riaz, Nadeem ; Reis-Filho, Jorge S. ; Powell, Simon ; Knowles, David A. ; Reznik, Ed ; Mishra, Bud ; Beroukhim, Rameen ; Zody, Michael C. ; Robine, Nicolas ; Oman, Kenji M. ; Sanchez, Carissa A. ; Kuhner, Mary K. ; Smith, Lucian P. ; Galipeau, Patricia C. ; Paulson, Thomas G. ; Reid, Brian J. ; Li, Xiaohong ; Wilkes, David ; Sboner, Andrea ; Mosquera, Juan Miguel ; Elemento, Olivier ; Imielinski, Marcin. / Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs. In: Cell. 2020 ; Vol. 183, No. 1. pp. 197-210.e32.

@article{d03c0f2ff84f4bfdbb3c0e18efb9b1c5,

title = "Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs",

abstract = "A novel computational approach for inferring and classifying patterns in cancer genome graphs uncovers three classes of complex structural variation with distinct tumor type and genomic distributions.",

keywords = "aneuploidy, cancer evolution, cancer genomics, chromothripsis, fragile sites, genome graphs, mutational processes, phasing, structural variation, superenhancers",

author = "Kevin Hadi and Xiaotong Yao and Behr, {Julie M.} and Aditya Deshpande and Charalampos Xanthopoulakis and Huasong Tian and Sarah Kudman and Joel Rosiene and Madison Darmofal and Joseph DeRose and Rick Mortensen and Adney, {Emily M.} and Alon Shaiber and Zoran Gajic and Michael Sigouros and Kenneth Eng and Wala, {Jeremiah A.} and Wrzeszczy{\'n}ski, {Kazimierz O.} and Kanika Arora and Minita Shah and Emde, {Anne Katrin} and Vanessa Felice and Frank, {Mayu O.} and Darnell, {Robert B.} and Mahmoud Ghandi and Franklin Huang and Sally Dewhurst and John Maciejowski and {de Lange}, Titia and Jeremy Setton and Nadeem Riaz and Reis-Filho, {Jorge S.} and Simon Powell and Knowles, {David A.} and Ed Reznik and Bud Mishra and Rameen Beroukhim and Zody, {Michael C.} and Nicolas Robine and Oman, {Kenji M.} and Sanchez, {Carissa A.} and Kuhner, {Mary K.} and Smith, {Lucian P.} and Galipeau, {Patricia C.} and Paulson, {Thomas G.} and Reid, {Brian J.} and Xiaohong Li and David Wilkes and Andrea Sboner and Mosquera, {Juan Miguel} and Olivier Elemento and Marcin Imielinski",

note = "Funding Information: M.I. thanks Dan Landau for bio-hermeneutic support; Elli Papaemmanuil for consultation in E???????; Matthew Meyerson, Scott Carter, and Cheng-Zhong Zhang for discussions early in the development of JaBbA; and Ron Zeira and Tomasz Imielinski for feedback on the JaBbA mathematical formulation. The authors thank Christopher Black and the NYGC ResComp team for high-performance computing support and Bionano genomics for assistance with optical mapping. M.I. X.Y, J.M.B. A.D. J.R. H.T. E.A. and Z.G. were supported by M.I.?s Burroughs Wellcome Fund Career Award for Medical Scientists, Doris Duke Clinical Foundation Clinical Scientist Development Award, Starr Cancer Consortium Award, National Institutes of Health (NIH) grant U24-CA15020, and Weill Cornell Medicine Department of Pathology and Laboratory Medicine startup funds. M.I. J.M. T.D.L. X.Y. and J.B. were supported by a Melanoma Research Alliance Team Science Award. K.H. was supported by a NIH/NCI F31 graduate research fellowship (F31-CA232465). M.D. was supported by an NIH F32 training grant given to the Tri-Institutional Computational Biology and Medicine PhD Program. R.B. received funding from the Fund for Innovation in Cancer Informatics. B.J.R. T.P. X.L. P.G. C.S. K.O. M.K. and L.S. are supported by NIH funding (P01-CA9195). The IBM-NYGC Cancer Alliance project was supported in part by a grant from the IBM corporation (IBM Watson Health) to the New York Genome Center, New York Genome Center philanthropic funds, and Rockefeller University grant UL1 TR000043 from the National Center for Advancing Translational Sciences (NCATS), and the NIH Clinical and Translational Science Award (CTSA) program. T.G.P. P.C.G. K.M.O. C.A.S. B.J.R. and X.L. were supported by NIH grants P01 CA91955 and P30 CA015704. M.K.K. and L.P.S. were supported by NIH grant P01 CA91955. Bud Mishra was supported by National Science Foundation grants CCF-0836649 and CCF-0926166 and a National Cancer Institute Physical Sciences-Oncology Center grant U54 CA193313-01. Graphical abstract was created with art from BioRender.com under academic license terms. Conceptualization, X.Y. K.H. J.B. J.W. R.B, T.D.L. J.M, J.S. N. Riaz, J.S.R.-F. S.P. and M.I.; Data Curation, X.Y. K.H. J.B, A.D. J.R. M.D, H.T. Z.G. M. Sigouros, K.E. K.O.W. K.A. M. Shah, A.K.E, V.F. M.O.F. M.G. F.H. J.M. N. Robine, K.M.O. C.A.S. M.K.K, L.P.S. P.C.G. T.G.P. X.L. D.W. A.S. J.M.M. and M.I.; Formal Analysis, J.B. K.H. X.Y, A.D. and M.I.; Funding Acquisition, R.D. P.G. B.R. O.E. and M.I.; Investigation, X.Y. J.B. K.H. A.D. and M.I.; Methodology, X.Y. J.B. K.H. A.D. D.K. E.R. B.M. and M.I.; Project Administration, M.I.; Resources, O.E. R.D. M.G. F.H. T.D.L, M.Z. N.R. T.P. P.G. R.S. X.L. B.R. and M.I.; Software, X.Y. J.B. C.X. and M.I.; Supervision, M.I.; Validation, X.Y. J.B. K.H. A.D. and M.I.; Visualization, X.Y. J.B. K.H. C.X. and M.I.; Writing ? Original Draft, M.I.; Writing ? Review & Editing, all authors. J.S.R.-F. reports receiving personal/consultancy fees from VolitionRx, Paige.AI, Goldman Sachs, REPARE Therapeutics, GRAIL, Ventana Medical Systems, Roche, Genentech, and InviCRO outside of the scope of the submitted work. Funding Information: M.I. thanks Dan Landau for bio-hermeneutic support; Elli Papaemmanuil for consultation in Eλληνικα; Matthew Meyerson, Scott Carter, and Cheng-Zhong Zhang for discussions early in the development of JaBbA; and Ron Zeira and Tomasz Imielinski for feedback on the JaBbA mathematical formulation. The authors thank Christopher Black and the NYGC ResComp team for high-performance computing support and Bionano genomics for assistance with optical mapping. M.I., X.Y, J.M.B., A.D., J.R., H.T., E.A., and Z.G. were supported by M.I.{\textquoteright}s Burroughs Wellcome Fund Career Award for Medical Scientists, Doris Duke Clinical Foundation Clinical Scientist Development Award, Starr Cancer Consortium Award, National Institutes of Health (NIH) grant U24-CA15020 , and Weill Cornell Medicine Department of Pathology and Laboratory Medicine startup funds. M.I., J.M., T.D.L., X.Y., and J.B. were supported by a Melanoma Research Alliance Team Science Award. K.H. was supported by a NIH/NCI F31 graduate research fellowship ( F31-CA232465 ). M.D. was supported by an NIH F32 training grant given to the Tri-Institutional Computational Biology and Medicine PhD Program. R.B. received funding from the Fund for Innovation in Cancer Informatics . B.J.R., T.P., X.L., P.G., C.S., K.O., M.K., and L.S. are supported by NIH funding ( P01-CA9195 ). The IBM-NYGC Cancer Alliance project was supported in part by a grant from the IBM corporation (IBM Watson Health) to the New York Genome Center, New York Genome Center philanthropic funds, and Rockefeller University grant UL1 TR000043 from the National Center for Advancing Translational Sciences (NCATS), and the NIH Clinical and Translational Science Award (CTSA) program. T.G.P., P.C.G., K.M.O., C.A.S., B.J.R., and X.L. were supported by NIH grants P01 CA91955 and P30 CA015704 . M.K.K. and L.P.S. were supported by NIH grant P01 CA91955 . Bud Mishra was supported by National Science Foundation grants CCF-0836649 and CCF-0926166 and a National Cancer Institute Physical Sciences-Oncology Center grant U54 CA193313-01 . Graphical abstract was created with art from BioRender.com under academic license terms. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2020",

month = oct,

day = "1",

doi = "10.1016/j.cell.2020.08.006",

language = "English (US)",

volume = "183",

pages = "197--210.e32",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

AU - Hadi, Kevin

AU - Yao, Xiaotong

AU - Behr, Julie M.

AU - Deshpande, Aditya

AU - Xanthopoulakis, Charalampos

AU - Tian, Huasong

AU - Kudman, Sarah

AU - Rosiene, Joel

AU - Darmofal, Madison

AU - DeRose, Joseph

AU - Mortensen, Rick

AU - Adney, Emily M.

AU - Shaiber, Alon

AU - Gajic, Zoran

AU - Sigouros, Michael

AU - Eng, Kenneth

AU - Wala, Jeremiah A.

AU - Wrzeszczyński, Kazimierz O.

AU - Arora, Kanika

AU - Shah, Minita

AU - Emde, Anne Katrin

AU - Felice, Vanessa

AU - Frank, Mayu O.

AU - Darnell, Robert B.

AU - Ghandi, Mahmoud

AU - Huang, Franklin

AU - Dewhurst, Sally

AU - Maciejowski, John

AU - de Lange, Titia

AU - Setton, Jeremy

AU - Riaz, Nadeem

AU - Reis-Filho, Jorge S.

AU - Powell, Simon

AU - Knowles, David A.

AU - Reznik, Ed

AU - Mishra, Bud

AU - Beroukhim, Rameen

AU - Zody, Michael C.

AU - Robine, Nicolas

AU - Oman, Kenji M.

AU - Sanchez, Carissa A.

AU - Kuhner, Mary K.

AU - Smith, Lucian P.

AU - Galipeau, Patricia C.

AU - Paulson, Thomas G.

AU - Reid, Brian J.

AU - Li, Xiaohong

AU - Wilkes, David

AU - Sboner, Andrea

AU - Mosquera, Juan Miguel

AU - Elemento, Olivier

AU - Imielinski, Marcin

N1 - Funding Information: M.I. thanks Dan Landau for bio-hermeneutic support; Elli Papaemmanuil for consultation in E???????; Matthew Meyerson, Scott Carter, and Cheng-Zhong Zhang for discussions early in the development of JaBbA; and Ron Zeira and Tomasz Imielinski for feedback on the JaBbA mathematical formulation. The authors thank Christopher Black and the NYGC ResComp team for high-performance computing support and Bionano genomics for assistance with optical mapping. M.I. X.Y, J.M.B. A.D. J.R. H.T. E.A. and Z.G. were supported by M.I.?s Burroughs Wellcome Fund Career Award for Medical Scientists, Doris Duke Clinical Foundation Clinical Scientist Development Award, Starr Cancer Consortium Award, National Institutes of Health (NIH) grant U24-CA15020, and Weill Cornell Medicine Department of Pathology and Laboratory Medicine startup funds. M.I. J.M. T.D.L. X.Y. and J.B. were supported by a Melanoma Research Alliance Team Science Award. K.H. was supported by a NIH/NCI F31 graduate research fellowship (F31-CA232465). M.D. was supported by an NIH F32 training grant given to the Tri-Institutional Computational Biology and Medicine PhD Program. R.B. received funding from the Fund for Innovation in Cancer Informatics. B.J.R. T.P. X.L. P.G. C.S. K.O. M.K. and L.S. are supported by NIH funding (P01-CA9195). The IBM-NYGC Cancer Alliance project was supported in part by a grant from the IBM corporation (IBM Watson Health) to the New York Genome Center, New York Genome Center philanthropic funds, and Rockefeller University grant UL1 TR000043 from the National Center for Advancing Translational Sciences (NCATS), and the NIH Clinical and Translational Science Award (CTSA) program. T.G.P. P.C.G. K.M.O. C.A.S. B.J.R. and X.L. were supported by NIH grants P01 CA91955 and P30 CA015704. M.K.K. and L.P.S. were supported by NIH grant P01 CA91955. Bud Mishra was supported by National Science Foundation grants CCF-0836649 and CCF-0926166 and a National Cancer Institute Physical Sciences-Oncology Center grant U54 CA193313-01. Graphical abstract was created with art from BioRender.com under academic license terms. Conceptualization, X.Y. K.H. J.B. J.W. R.B, T.D.L. J.M, J.S. N. Riaz, J.S.R.-F. S.P. and M.I.; Data Curation, X.Y. K.H. J.B, A.D. J.R. M.D, H.T. Z.G. M. Sigouros, K.E. K.O.W. K.A. M. Shah, A.K.E, V.F. M.O.F. M.G. F.H. J.M. N. Robine, K.M.O. C.A.S. M.K.K, L.P.S. P.C.G. T.G.P. X.L. D.W. A.S. J.M.M. and M.I.; Formal Analysis, J.B. K.H. X.Y, A.D. and M.I.; Funding Acquisition, R.D. P.G. B.R. O.E. and M.I.; Investigation, X.Y. J.B. K.H. A.D. and M.I.; Methodology, X.Y. J.B. K.H. A.D. D.K. E.R. B.M. and M.I.; Project Administration, M.I.; Resources, O.E. R.D. M.G. F.H. T.D.L, M.Z. N.R. T.P. P.G. R.S. X.L. B.R. and M.I.; Software, X.Y. J.B. C.X. and M.I.; Supervision, M.I.; Validation, X.Y. J.B. K.H. A.D. and M.I.; Visualization, X.Y. J.B. K.H. C.X. and M.I.; Writing ? Original Draft, M.I.; Writing ? Review & Editing, all authors. J.S.R.-F. reports receiving personal/consultancy fees from VolitionRx, Paige.AI, Goldman Sachs, REPARE Therapeutics, GRAIL, Ventana Medical Systems, Roche, Genentech, and InviCRO outside of the scope of the submitted work. Funding Information: M.I. thanks Dan Landau for bio-hermeneutic support; Elli Papaemmanuil for consultation in Eλληνικα; Matthew Meyerson, Scott Carter, and Cheng-Zhong Zhang for discussions early in the development of JaBbA; and Ron Zeira and Tomasz Imielinski for feedback on the JaBbA mathematical formulation. The authors thank Christopher Black and the NYGC ResComp team for high-performance computing support and Bionano genomics for assistance with optical mapping. M.I., X.Y, J.M.B., A.D., J.R., H.T., E.A., and Z.G. were supported by M.I.’s Burroughs Wellcome Fund Career Award for Medical Scientists, Doris Duke Clinical Foundation Clinical Scientist Development Award, Starr Cancer Consortium Award, National Institutes of Health (NIH) grant U24-CA15020 , and Weill Cornell Medicine Department of Pathology and Laboratory Medicine startup funds. M.I., J.M., T.D.L., X.Y., and J.B. were supported by a Melanoma Research Alliance Team Science Award. K.H. was supported by a NIH/NCI F31 graduate research fellowship ( F31-CA232465 ). M.D. was supported by an NIH F32 training grant given to the Tri-Institutional Computational Biology and Medicine PhD Program. R.B. received funding from the Fund for Innovation in Cancer Informatics . B.J.R., T.P., X.L., P.G., C.S., K.O., M.K., and L.S. are supported by NIH funding ( P01-CA9195 ). The IBM-NYGC Cancer Alliance project was supported in part by a grant from the IBM corporation (IBM Watson Health) to the New York Genome Center, New York Genome Center philanthropic funds, and Rockefeller University grant UL1 TR000043 from the National Center for Advancing Translational Sciences (NCATS), and the NIH Clinical and Translational Science Award (CTSA) program. T.G.P., P.C.G., K.M.O., C.A.S., B.J.R., and X.L. were supported by NIH grants P01 CA91955 and P30 CA015704 . M.K.K. and L.P.S. were supported by NIH grant P01 CA91955 . Bud Mishra was supported by National Science Foundation grants CCF-0836649 and CCF-0926166 and a National Cancer Institute Physical Sciences-Oncology Center grant U54 CA193313-01 . Graphical abstract was created with art from BioRender.com under academic license terms. Publisher Copyright: © 2020 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - A novel computational approach for inferring and classifying patterns in cancer genome graphs uncovers three classes of complex structural variation with distinct tumor type and genomic distributions.

AB - A novel computational approach for inferring and classifying patterns in cancer genome graphs uncovers three classes of complex structural variation with distinct tumor type and genomic distributions.

KW - aneuploidy

KW - cancer evolution

KW - cancer genomics

KW - chromothripsis

KW - fragile sites

KW - genome graphs

KW - mutational processes

KW - phasing

KW - structural variation

KW - superenhancers

UR - http://www.scopus.com/inward/record.url?scp=85091663377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85091663377&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2020.08.006

DO - 10.1016/j.cell.2020.08.006

M3 - Article

C2 - 33007263

AN - SCOPUS:85091663377

VL - 183

SP - 197-210.e32

JO - Cell

JF - Cell

SN - 0092-8674

IS - 1

ER -

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

Abstract

Keywords

ASJC Scopus subject areas

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