Distinct sleep disturbance profiles among patients with gynecologic cancer receiving chemotherapy

Rachel A. Pozzar, Marilyn J. Hammer, Steven M. Paul, Bruce A. Cooper, Kord M. Kober, Yvette P. Conley, Jon D. Levine, Christine Miaskowski

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: In a sample of patients with gynecologic cancer receiving chemotherapy, we sought to identify subgroups of patients with distinct sleep disturbance profiles and assess for differences in patient characteristics and the severity of co-occurring symptoms among these subgroups. Methods: Adults with gynecologic cancer (n = 232) completed questionnaires six times over two chemotherapy cycles. Sleep disturbance was assessed using the General Sleep Disturbance Scale (GSDS). Clinically meaningful sleep disturbance was defined as a GSDS total score of ≥43. Subgroups of patients with distinct sleep disturbance profiles were identified using latent profile analysis. Differences in patient characteristics and co-occurring symptoms were assessed using Chi-square, Kruskal Wallis, and one-way analysis of variance. Results: Four distinct sleep disturbance profiles were identified: Low (18.5%), Moderate (43.6%), High (29.3%), and Very High (8.6%). Compared to the Low class, patients in the other three classes had lower functional status scores and higher levels of depressive symptoms, trait anxiety, and morning and evening fatigue. Compared to the Low class, patients in the Very High class were younger, had a higher body mass index, and were more likely to report a diagnosis of depression or back pain. Conclusions: Over 80% of the patients with gynecologic cancer reported sleep disturbance that persisted over two cycles of chemotherapy. Patients in the Very High class experienced problems with both sleep initiation and maintenance. Clinicians should routinely assess sleep disturbance alongside depression, anxiety, and fatigue. Interventions that target the underlying mechanisms of these co-occurring symptoms are warranted.

Original languageEnglish (US)
JournalGynecologic oncology
DOIs
StateAccepted/In press - 2021

Keywords

  • Chemotherapy
  • Depression
  • Fatigue
  • Insomnia
  • Ovarian neoplasms
  • Pain
  • Sleep disturbance
  • Uterine neoplasms

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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