TY - JOUR
T1 - Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli
AU - Cunningham-Bussel, Amy C.
AU - Root, James C.
AU - Butler, Tracy
AU - Tuescher, Oliver
AU - Pan, Hong
AU - Epstein, Jane
AU - Weisholtz, Daniel S.
AU - Pavony, Michelle
AU - Silverman, Michael E.
AU - Goldstein, Martin S.
AU - Altemus, Margaret
AU - Cloitre, Marylene
AU - LeDoux, Joseph
AU - McEwen, Bruce
AU - Stern, Emily
AU - Silbersweig, David
N1 - Funding Information:
Funding for this study was provided by NIMH Grant P50 MH58911-S1; the NIMH had no further role in study.
PY - 2009/6
Y1 - 2009/6
N2 - The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant levels of cortisol secretion. Here we report on the relationship between the amplitude of diurnal cortisol secretion, measured across 3 typical days in 18 healthy individuals, and blood oxygen level dependant (BOLD) response in limbic fear/stress circuits, elicited by in-scanner presentation of emotionally negative stimuli, specifically, images of the World Trade Center (WTC) attack. Results indicate that subjects who secrete a greater amplitude of cortisol diurnally demonstrate less brain activation in limbic regions, including the amygdala and hippocampus/parahippocampus, and hypothalamus during exposure to traumatic WTC-related images. Such initial findings can begin to link our understanding, in humans, of the relationship between the diurnal amplitude of a hormone integral to the stress response, and those neuroanatomical regions that are implicated as both modulating and being modulated by that response.
AB - The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant levels of cortisol secretion. Here we report on the relationship between the amplitude of diurnal cortisol secretion, measured across 3 typical days in 18 healthy individuals, and blood oxygen level dependant (BOLD) response in limbic fear/stress circuits, elicited by in-scanner presentation of emotionally negative stimuli, specifically, images of the World Trade Center (WTC) attack. Results indicate that subjects who secrete a greater amplitude of cortisol diurnally demonstrate less brain activation in limbic regions, including the amygdala and hippocampus/parahippocampus, and hypothalamus during exposure to traumatic WTC-related images. Such initial findings can begin to link our understanding, in humans, of the relationship between the diurnal amplitude of a hormone integral to the stress response, and those neuroanatomical regions that are implicated as both modulating and being modulated by that response.
KW - Amygdala
KW - Cortisol
KW - Hippocampus
KW - Medial prefrontal cortex
KW - Neuroimaging
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=64049093351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64049093351&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2008.11.011
DO - 10.1016/j.psyneuen.2008.11.011
M3 - Article
C2 - 19135805
AN - SCOPUS:64049093351
SN - 0306-4530
VL - 34
SP - 694
EP - 704
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
IS - 5
ER -