@article{01a3000895a549f9b276626c4fac15ef,
title = "DNA-Coated Microspheres and Their Colloidal Superstructures",
abstract = "Reversible and specific interaction between single-stranded DNA on colloidal particles have opened up a new path way of building up colloidal superstructures. DNA-coated microspheres can be bound with other particles with complementary DNA brushes below the melting temperature and can be unbound above the melting temperature. However, due to their random Brownian motion, the particles form random (or glassy) structures in most cases or small crystals when cooling is extremely slow. Therefore, toward programmed colloidal superstructures of DNA-coated microspheres, they should reconfigure their kinetically trapped random structure to equilibrium crystalline structures. While nanoparticles can be rearranged into a crystalline structure by a simple conformational change of relatively long DNA brush, microspheres with short DNA brushes cannot be rearranged only by a conformational change of brush. Instead, sub-diffusion of bound DNA-coated microspheres is necessary which can be possible only with uniform DNA coating with high areal density on microspheres. In this article, we have reviewed methods for the synthesis of high-density DNA-coated microspheres and their assembly into crystalline structures. We also discuss future research direction of DNA-coated microspheres. [Figure not available: see fulltext.].",
keywords = "DNA coating, DNA hybridization, crystallization, microsphere, self-assembly, sub-diffusion",
author = "Jeongbin Moon and Jo, {In Seong} and Etienne Ducrot and Oh, {Joon Suk} and Pine, {David J.} and Yi, {Gi Ra}",
note = "Funding Information: 1. Introduction that these particles can assemble into various crystalline struc-tures directed by their surface DNA programmed interactions.省??? DNA is a copolymer formed by four distinctive monomers, More recently, DNA-coated nanoparticles were combined with namely, the nucleotides or bases: adenine (A), guanine (G), the DNA origami to form more complex structures. For instance, cytosine (C) and thymine (T). Adenine and guanine can form chiral helical structures of gold nanoparticles can be formed on selective hydrogen bonds with thymine and cytosine, respec-tubular DNA origami, in which chirality can be controlled by tively.?Therefore, a strand of DNA can recognize its comple-design.猃?-猃?Gang et al. reported more recently that diamond-like mentary strand and self-assemble into a double helical structure, open structures of gold nanoparticles can be assembled using or double-stranded DNA, with hydrogen bonds between com-tetrahedral DNA origami cages and DNA-coated gold nanopar-plementary bases keeping the two chains together. For the past ticles.猃? more than 球爀 years, such seqnucee-specific hybridization has DNA-mediated colloidal assembly was extended to micron-been applied to build up structured materials. DNA origami sized particles with the final goal of building up photonic crystals was the first attempt at using DNA as a tool to generate various or meta-materials.猃稁?As ?micron-sized particles can be observed nanostructures.琁?T?his strategy relies on the self-assembly of a by optical or confocal microscopy, DNA-coated microspheres myriad of precisely designed DNA strands that fold into the can also be utilized as model systems to understand how atoms desired structure. Subsequently, DNA strands with a thiol end-or molecules assemble into complex structures.球?-球?To increase group were immobilized on the surface of gold nanoparticles the versatility of the technique and broaden their applications, by thiol-gold conjugation reaction.?The resulting DNA-coated several new conjugation methods have been developed to coat nanoparticles selectively bound to other particles coated with particles with high-density DNA brushes. This approach is essen-complementary DNA sequences. Mirkin et al. demonstrated tial for DNA-mediated assembly of colloidal particles made of a large spectrum of materials. Acknowledgments: This researchwas supported by theNational Research In this article, we first review the methods for coating DNA FoundationGrant funded by the Korean Government (球爃猃礀M?A? 眃B?? ?稂I?on ?microspheres made of polymer, silica, titania, or organosil-and the KoreaInstituteofIndustrial Technology (kitechJA-猃礁爃?爃瘃省? kitechica. We discuss how the areal density of DNA strands on a surface IZ-猃?-爃? 甃笂I. David J. Pine acknowledges support from they U RSeAsremarch can be varied significantly depending on the DNA conjugation Office (W ?猃?NF-猃?-猁爃?球?) and US Department of Ene?rgy笃 (D笃E?-SC)me.?thod? ? ranging from few thousands to millions of strands per 猁? m particle. We further discuss how those DNA-coated parti- Publisher Copyright: {\textcopyright} 2018, The Polymer Society of Korea and Springer Nature B.V.",
year = "2018",
month = dec,
day = "1",
doi = "10.1007/s13233-018-6151-8",
language = "English (US)",
volume = "26",
pages = "1085--1094",
journal = "Macromolecular Research",
issn = "1598-5032",
publisher = "Polymer Society of Korea",
number = "12",
}