Abstract
Cruciforms represent a novel DNA state with unique physical and biological properties, including the ability to undergo branch migration in appropriate sequence backgrounds. Recent results establish a preferred geometry of immobile cruciforms in Mg2+ solution, the rate of branch migration, and the binding properties of cruciforms for proteins and small molecule ligands. A structure has been determined for three-arm branches with unpaired bases at the branch.
Original language | English (US) |
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Pages (from-to) | 365-371 |
Number of pages | 7 |
Journal | Current Opinion in Structural Biology |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1994 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology