DNA cruciforms

Neville R. Kallenbach; Min Zhong

doi:10.1016/S0959-440X(94)90104-X

DNA cruciforms

Neville R. Kallenbach, Min Zhong

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Cruciforms represent a novel DNA state with unique physical and biological properties, including the ability to undergo branch migration in appropriate sequence backgrounds. Recent results establish a preferred geometry of immobile cruciforms in Mg²⁺ solution, the rate of branch migration, and the binding properties of cruciforms for proteins and small molecule ligands. A structure has been determined for three-arm branches with unpaired bases at the branch.

Original language	English (US)
Pages (from-to)	365-371
Number of pages	7
Journal	Current Opinion in Structural Biology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/S0959-440X(94)90104-X
State	Published - Jun 1994

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(94)90104-X

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abstract = "Cruciforms represent a novel DNA state with unique physical and biological properties, including the ability to undergo branch migration in appropriate sequence backgrounds. Recent results establish a preferred geometry of immobile cruciforms in Mg2+ solution, the rate of branch migration, and the binding properties of cruciforms for proteins and small molecule ligands. A structure has been determined for three-arm branches with unpaired bases at the branch.",

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