DNA cruciforms

Neville R. Kallenbach; Min Zhong

doi:10.1016/S0959-440X(94)90104-X

DNA cruciforms

Neville R. Kallenbach, Min Zhong

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Cruciforms represent a novel DNA state with unique physical and biological properties, including the ability to undergo branch migration in appropriate sequence backgrounds. Recent results establish a preferred geometry of immobile cruciforms in Mg²⁺ solution, the rate of branch migration, and the binding properties of cruciforms for proteins and small molecule ligands. A structure has been determined for three-arm branches with unpaired bases at the branch.

Original language	English (US)
Pages (from-to)	365-371
Number of pages	7
Journal	Current Opinion in Structural Biology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/S0959-440X(94)90104-X
State	Published - Jun 1994

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(94)90104-X

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title = "DNA cruciforms",

abstract = "Cruciforms represent a novel DNA state with unique physical and biological properties, including the ability to undergo branch migration in appropriate sequence backgrounds. Recent results establish a preferred geometry of immobile cruciforms in Mg2+ solution, the rate of branch migration, and the binding properties of cruciforms for proteins and small molecule ligands. A structure has been determined for three-arm branches with unpaired bases at the branch.",

author = "Kallenbach, {Neville R.} and Min Zhong",

note = "Funding Information: We thank our colleagues for providing reprints and preprints of articles and for helpful discussions. Work from the authors' laboratory is suplx~rted by National Institutes of Health grant CA24101. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "1994",

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doi = "10.1016/S0959-440X(94)90104-X",

language = "English (US)",

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AU - Kallenbach, Neville R.

AU - Zhong, Min

N1 - Funding Information: We thank our colleagues for providing reprints and preprints of articles and for helpful discussions. Work from the authors' laboratory is suplx~rted by National Institutes of Health grant CA24101. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 1994/6

Y1 - 1994/6

N2 - Cruciforms represent a novel DNA state with unique physical and biological properties, including the ability to undergo branch migration in appropriate sequence backgrounds. Recent results establish a preferred geometry of immobile cruciforms in Mg2+ solution, the rate of branch migration, and the binding properties of cruciforms for proteins and small molecule ligands. A structure has been determined for three-arm branches with unpaired bases at the branch.

AB - Cruciforms represent a novel DNA state with unique physical and biological properties, including the ability to undergo branch migration in appropriate sequence backgrounds. Recent results establish a preferred geometry of immobile cruciforms in Mg2+ solution, the rate of branch migration, and the binding properties of cruciforms for proteins and small molecule ligands. A structure has been determined for three-arm branches with unpaired bases at the branch.

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DNA cruciforms

Abstract

ASJC Scopus subject areas

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