DNA-Functionalized 100 nm Polymer Nanoparticles from Block Copolymer Micelles

Saerom Lee, Jeong Hoon Yoon, In Seong Jo, Joon Suk Oh, David J. Pine, Tae Soup Shim, Gi Ra Yi

Research output: Contribution to journalArticlepeer-review


DNA-mediated self-assembly of colloidal particles is one of the most promising approaches for constructing colloidal superstructures. For nanophotonic materials and devices, DNA-functionalized colloids with diameters of around 100 nm are essential building blocks. Here, we demonstrate a strategy for synthesizing DNA-functionalized polymer nanoparticles (DNA-polyNPs) in the size range of 55-150 nm using block copolymer micelles as a template. Diblock copolymers of polystyrene-b-poly(ethylene oxide) with an azide end group (PS-b-PEO-N3) are first formed into spherical micelles. Then, the micelle cores are swollen with the styrene monomer and polymerized, thus producing PS NPs with PEO brushes and azide functional end groups. DNA strands are conjugated onto the ends of the PEO brushes through a strain-promoted alkyne-azide cycloaddition reaction, resulting in a DNA density of more than one DNA strand per 12.6 nm2 for 70 nm particles. The DNA-polyNPs with complementary sequences enable the formation of CsCl-type colloidal superstructure by DNA binding.

Original languageEnglish (US)
Pages (from-to)11042-11048
Number of pages7
Issue number37
StatePublished - Sep 18 2018

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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