DNA nanotechnology

Nadrian C. Seeman; Hanadi F. Sleiman

doi:10.1038/natrevmats.2017.68

DNA nanotechnology

Nadrian C. Seeman, Hanadi F. Sleiman

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

DNA is the molecule that stores and transmits genetic information in biological systems. The field of DNA nanotechnology takes this molecule out of its biological context and uses its information to assemble structural motifs and then to connect them together. This field has had a remarkable impact on nanoscience and nanotechnology, and has been revolutionary in our ability to control molecular self-assembly. In this Review, we summarize the approaches used to assemble DNA nanostructures and examine their emerging applications in areas such as biophysics, diagnostics, nanoparticle and protein assembly, biomolecule structure determination, drug delivery and synthetic biology. The introduction of orthogonal interactions into DNA nanostructures is discussed, and finally, a perspective on the future directions of this field is presented.

Original language	English (US)
Article number	17068
Journal	Nature Reviews Materials
Volume	3
DOIs	https://doi.org/10.1038/natrevmats.2017.68
State	Published - Nov 8 2017

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Energy (miscellaneous)
Surfaces, Coatings and Films
Materials Chemistry

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10.1038/natrevmats.2017.68

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abstract = "DNA is the molecule that stores and transmits genetic information in biological systems. The field of DNA nanotechnology takes this molecule out of its biological context and uses its information to assemble structural motifs and then to connect them together. This field has had a remarkable impact on nanoscience and nanotechnology, and has been revolutionary in our ability to control molecular self-assembly. In this Review, we summarize the approaches used to assemble DNA nanostructures and examine their emerging applications in areas such as biophysics, diagnostics, nanoparticle and protein assembly, biomolecule structure determination, drug delivery and synthetic biology. The introduction of orthogonal interactions into DNA nanostructures is discussed, and finally, a perspective on the future directions of this field is presented.",

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AB - DNA is the molecule that stores and transmits genetic information in biological systems. The field of DNA nanotechnology takes this molecule out of its biological context and uses its information to assemble structural motifs and then to connect them together. This field has had a remarkable impact on nanoscience and nanotechnology, and has been revolutionary in our ability to control molecular self-assembly. In this Review, we summarize the approaches used to assemble DNA nanostructures and examine their emerging applications in areas such as biophysics, diagnostics, nanoparticle and protein assembly, biomolecule structure determination, drug delivery and synthetic biology. The introduction of orthogonal interactions into DNA nanostructures is discussed, and finally, a perspective on the future directions of this field is presented.

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DNA nanotechnology

Abstract

ASJC Scopus subject areas

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