DNA promoter hypermethylation in saliva for the early diagnosis of oral cancer.

C. T. Viet, Richard C.K. Jordan, Brian L. Schmidt

Research output: Contribution to journalArticle

Abstract

Oral health care professionals could drastically improve the quality of life for patients with potentially malignant oral lesions by using a noninvasive test that could be used to detect cancer using saliva. Promoter DNA hypermethylation is a critical step in oral carcinogenesis and has a number of significant advantages over genetic and protein diagnostic markers. Methylight is a recently developed assay that rapidly quantifies promoter hypermethylation and could potentially be applied into a clinical setting.

Original languageEnglish (US)
Pages (from-to)844-849
Number of pages6
JournalJournal of the California Dental Association
Volume35
Issue number12
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Dentistry(all)

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