DNA structural engineering using immobile junctions

Nadrian C. Seeman

doi:10.1016/S0959-440X(05)80092-2

DNA structural engineering using immobile junctions

Nadrian C. Seeman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Immobile DNA branched junctions are a complex macromolecular system whose structural features are readily tractable to a simple sequence-design algorithm based on the minimization of sequence symmetry. This algorithm has been applied to the construction of Holliday recombination analogs and to multiply-connected geometrical objects, including a DNA molecule with the connectivity of a cube.

Original language	English (US)
Pages (from-to)	653-661
Number of pages	9
Journal	Current Opinion in Structural Biology
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/S0959-440X(05)80092-2
State	Published - Aug 1991

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(05)80092-2

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title = "DNA structural engineering using immobile junctions",

abstract = "Immobile DNA branched junctions are a complex macromolecular system whose structural features are readily tractable to a simple sequence-design algorithm based on the minimization of sequence symmetry. This algorithm has been applied to the construction of Holliday recombination analogs and to multiply-connected geometrical objects, including a DNA molecule with the connectivity of a cube.",

author = "Seeman, {Nadrian C.}",

note = "Funding Information: This research has been supported by grant N00014-89-J-3078 from the Office of Naval Research and by grant GM-29554 from the National Institutes of Health.",

year = "1991",

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PY - 1991/8

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N2 - Immobile DNA branched junctions are a complex macromolecular system whose structural features are readily tractable to a simple sequence-design algorithm based on the minimization of sequence symmetry. This algorithm has been applied to the construction of Holliday recombination analogs and to multiply-connected geometrical objects, including a DNA molecule with the connectivity of a cube.

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DNA structural engineering using immobile junctions

Abstract

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