DNA structural engineering using immobile junctions

Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


Immobile DNA branched junctions are a complex macromolecular system whose structural features are readily tractable to a simple sequence-design algorithm based on the minimization of sequence symmetry. This algorithm has been applied to the construction of Holliday recombination analogs and to multiply-connected geometrical objects, including a DNA molecule with the connectivity of a cube.

Original languageEnglish (US)
Pages (from-to)653-661
Number of pages9
JournalCurrent Opinion in Structural Biology
Issue number4
StatePublished - Aug 1991

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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