TY - JOUR
T1 - DNA synthesis and the mitotic cycle in frog kidney cells cultivated in vitro
AU - Malamud, D.
N1 - Funding Information:
1 Supported by U.S.P.1I.S. Grant CA-06439 to W. Auclair and American Cancer Sot. Inst.
PY - 1967/2
Y1 - 1967/2
N2 - Frog kidney cells in tissue culture exhibit a lag period of about 48 hr before the onset of DNA synthesis. During this time the number of cells incorporating nucleoside into rapidly labeled RNA decreases for 10-12 hr, then increases until 48 hr. Coincident with the start of DNA synthesis there is a sharp drop in the synthesis of rapidly labeled RNA. The generation cycle of frog kidney cells was determined: G1 + telophase = 16 hr, S = 22.3 hr, G2 + prophase = 7.7 hr, T = 46 hr.
AB - Frog kidney cells in tissue culture exhibit a lag period of about 48 hr before the onset of DNA synthesis. During this time the number of cells incorporating nucleoside into rapidly labeled RNA decreases for 10-12 hr, then increases until 48 hr. Coincident with the start of DNA synthesis there is a sharp drop in the synthesis of rapidly labeled RNA. The generation cycle of frog kidney cells was determined: G1 + telophase = 16 hr, S = 22.3 hr, G2 + prophase = 7.7 hr, T = 46 hr.
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U2 - 10.1016/0014-4827(67)90179-6
DO - 10.1016/0014-4827(67)90179-6
M3 - Article
C2 - 6021922
AN - SCOPUS:0014051117
SN - 0014-4827
VL - 45
SP - 277
EP - 280
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 2
ER -