DNN-assisted statistical analysis of a model of local cortical circuits

Yaoyu Zhang, Lai Sang Young

Research output: Contribution to journalArticlepeer-review


In neuroscience, computational modeling is an effective way to gain insight into cortical mechanisms, yet the construction and analysis of large-scale network models—not to mention the extraction of underlying principles—are themselves challenging tasks, due to the absence of suitable analytical tools and the prohibitive costs of systematic numerical exploration of high-dimensional parameter spaces. In this paper, we propose a data-driven approach assisted by deep neural networks (DNN). The idea is to first discover certain input-output relations, and then to leverage this information and the superior computation speeds of the well-trained DNN to guide parameter searches and to deduce theoretical understanding. To illustrate this novel approach, we used as a test case a medium-size network of integrate-and-fire neurons intended to model local cortical circuits. With the help of an accurate yet extremely efficient DNN surrogate, we revealed the statistics of model responses, providing a detailed picture of model behavior. The information obtained is both general and of a fundamental nature, with direct application to neuroscience. Our results suggest that the methodology proposed can be scaled up to larger and more complex biological networks when used in conjunction with other techniques of biological modeling.

Original languageEnglish (US)
Article number20139
JournalScientific reports
Issue number1
StatePublished - Dec 2020

ASJC Scopus subject areas

  • General


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