Dose frequency randomized controlled trial for Dynamic Temporal and Tactile Cueing (DTTC) treatment for childhood apraxia of speech: protocol paper

Jenya Iuzzini-Seigel, Julie Case, Maria I. Grigos, Shelley L. Velleman, Donna Thomas, Elizabeth Murray

Research output: Contribution to journalArticlepeer-review


Background: Childhood apraxia of speech (CAS) is a pediatric motor-based speech sound disorder that requires a specialized approach to intervention. The extant literature on the treatment of CAS commonly recommends intensive treatment using a motor-based approach, with some of the best evidence supporting the use of Dynamic Temporal and Tactile Cueing (DTTC). To date, a rigorous and systematic comparison of high and low dose frequency (i.e., frequency of therapy sessions) has not been undertaken for DTTC, resulting in a lack of evidence to guide decisions about the optimal treatment schedule for this intervention. The current study aims to fill this gap in knowledge by comparing treatment outcomes when dose frequency is varied. Methods: A randomized controlled trial will be conducted to examine the efficacy of low versus high dose frequency on DTTC treatment outcomes in children with CAS. A target of 60 children, 2;6–7;11 years of age, will be recruited to participate in this study. Treatment will be provided in the community setting by speech-language pathologists who have completed specialized training administering DTTC in a research reliable manner. True randomization with concealed allocation will be used to assign children to either the low or high dose frequency group. Treatment will be administered in 1-h sessions either 4 times per week over a 6-week period (high dose) or 2 times per week over a 12-week period (low dose). To measure treatment gains, probe data will be collected before treatment, during treatment, and 1 day, 1 week, 4 weeks, and 12 weeks post-treatment. Probe data will consist of customized treated words and a standard set of untreated words to assess generalization of treatment gains. The primary outcome variable will be whole word accuracy, encompassing segmental, phonotactic, and suprasegmental accuracy. Discussion: This will be the first randomized controlled trial to evaluate dose frequency for DTTC treatment in children with CAS. Trial registration: identifier NCT05675306, January 6, 2023.

Original languageEnglish (US)
Article number263
JournalBMC Pediatrics
Issue number1
StatePublished - Dec 2023


  • Childhood apraxia of speech
  • DTTC
  • Dose frequency
  • Motor speech
  • Randomized controlled trial
  • Treatment
  • Treatment schedule

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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