double-time is a novel Drosophila clock gene that regulates period protein accumulation

Jeffrey L. Price, Justin Blau, Adrian Rothenfluh, Marla Abodeely, Brian Kloss, Michael W. Young

Research output: Contribution to journalArticlepeer-review


We have isolated three alleles of a novel Drosophila clock gene, double- time (dbt). Short- (dbt(S)) and longperiod (dbt(L)) mutants alter both behavioral rhythmicity and molecular oscillations from previously identified clock genes, period and timeless. A third allele, dbt(P), causes pupal lethality and eliminates circadian cycling of per and tim gene products in larvae. In dbt(P) mutants, PER proteins constitutively accumulate, remain hypophosphorylated, and no longer depend on TIM proteins for their accumulation. We propose that the normal function of DOUBLETIME protein is to reduce the stability and thus the level of accumulation of monomeric PER proteins. This would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity.

Original languageEnglish (US)
Pages (from-to)83-95
Number of pages13
Issue number1
StatePublished - Jul 10 1998

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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