Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health

Romy Roy, Shamsudheen Marakkar, Munawar Peringadi Vayalil, Alisha Shahanaz, Athira Panicker Anil, Shameer Kunnathpeedikayil, Ishaan Rawal, Kavya Shetty, Zahrah Shameer, Saraswathi Sathees, Adarsh Pooradan Prasannakumar, Oommen Kaleeckal Mathew, Laksh Minarayanan Subramanian, Khader Shameer, Kamlesh K. Yadav

Research output: Contribution to journalReview articlepeer-review


The drug-food interaction brings forth changes in the clinical effects of drugs. While favourable interactions bring positive clinical outcomes, unfavourable interactions may lead to toxicity. This article reviews the impact of food intake on drug-food interactions, the clinical effects of drugs, and the effect of drug-food in correlation with diet and precision medicine. Emerging areas in drug-food interactions are the food-genome interface (nutrigenomics) and nu-trigenetics. Understanding the molecular basis of food ingredients, including genomic sequencing and pharmacological implications of food molecules, helps to reduce the impact of drug-food interactions. Various strategies are being leveraged to alleviate drug-food interactions; measures including patient engagement, digital health, approaches involving machine intelligence, and big data are a few of them. Furthermore, delineating the molecular communications across diet-microbiome-drug-food-drug interactions in a pharmacomicrobiome framework may also play a vital role in personalized nutrition. Determining nutrient-gene interactions aids in making nutrition deeply personalized and helps mitigate unwanted drug-food interactions, chronic diseases, and adverse events from their onset. Translational bioinformatics approaches could play an essential role in the next generation of drug-food interaction research. In this landscape review, we discuss important tools, databases, and approaches along with key challenges and opportunities in drug-food interaction and its immediate impact on precision medicine.

Original languageEnglish (US)
Pages (from-to)27-50
Number of pages24
JournalRecent Advances in Food, Nutrition and Agriculture
Issue number1
StatePublished - Apr 2022


  • Drug-food interactions
  • big data
  • machine intelligence
  • nutrigenomics
  • pharmacomicrobiome
  • precision medicine

ASJC Scopus subject areas

  • Food Science
  • Agronomy and Crop Science


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