TY - JOUR
T1 - DSM-5 substance use disorder symptom clusters and HIV antiretroviral therapy (ART) adherence
AU - Paschen-Wolff, Margaret M.
AU - Campbell, Aimee N.C.
AU - Tross, Susan
AU - Choo, Tse Hwei
AU - Pavlicova, Martina
AU - Jarlais, Don Des
N1 - Funding Information:
This work was supported by the National Institutes of Health, National Institute on Drug Abuse under grant R01 DA035707 (Multiple PIs: Don Des Jarlais, Ph.D. and Aimee Campbell, Ph.D.) and R01 DA003574 (PI: Des Jarlais). Dr. Margaret Paschen-Wolff was supported by the National Institute of Mental Health at the HIV Center for Clinical and Behavioral Studies at the NY State Psychiatric Institute and Columbia University under a training grant T32 MH019139 (PI: Theodorus Sandfort) and P30 MH43520 (Center Principal Investigator: Robert Remien, Ph.D.). The authors would like to acknowledge our research assistants (Laurel Weaver, Jeannie Ortiz and Martha Nelson) and our study participants.
Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/5/3
Y1 - 2020/5/3
N2 - This study examines self-reported 30-day antiretroviral therapy (ART) adherence among 101 people living with HIV and substance use disorders (SUD) in New York City in terms of Diagnostic and Statistical Manual–5th Edition (DSM-5) SUD symptom clusters: impaired control, social impairment, risky use and pharmacological criteria. Overall, 60.4% met DSM-5 criteria for stimulant, 55.5% for alcohol, 34.7% for cannabis and 25.7% for opioid SUD. Of the 76 participants with a current ART prescription, 75.3% reported at least 90% 30-day adherence. Participants with vs. without alcohol SUD were significantly less likely to report ART adherence (64.3% vs. 88.2%, p =.017). Endorsement of social impairment significantly differed among adherent vs. non-adherent participants with alcohol SUDs (74.1% vs. 100%, p =.038) and with opioid SUDs (94.1% vs. 50.0%, p =.040). Understanding specific SUD symptom clusters may assist providers and patients in developing strategies to improve ART adherence.
AB - This study examines self-reported 30-day antiretroviral therapy (ART) adherence among 101 people living with HIV and substance use disorders (SUD) in New York City in terms of Diagnostic and Statistical Manual–5th Edition (DSM-5) SUD symptom clusters: impaired control, social impairment, risky use and pharmacological criteria. Overall, 60.4% met DSM-5 criteria for stimulant, 55.5% for alcohol, 34.7% for cannabis and 25.7% for opioid SUD. Of the 76 participants with a current ART prescription, 75.3% reported at least 90% 30-day adherence. Participants with vs. without alcohol SUD were significantly less likely to report ART adherence (64.3% vs. 88.2%, p =.017). Endorsement of social impairment significantly differed among adherent vs. non-adherent participants with alcohol SUDs (74.1% vs. 100%, p =.038) and with opioid SUDs (94.1% vs. 50.0%, p =.040). Understanding specific SUD symptom clusters may assist providers and patients in developing strategies to improve ART adherence.
KW - Antiretroviral therapy
KW - DSM-5
KW - HIV/AIDS
KW - medication adherence
KW - substance use disorders
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U2 - 10.1080/09540121.2019.1686600
DO - 10.1080/09540121.2019.1686600
M3 - Article
C2 - 31682153
AN - SCOPUS:85074784217
SN - 0954-0121
VL - 32
SP - 645
EP - 650
JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
IS - 5
ER -