Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents

Debarati M. Tagore; K. Ingrid Sprinz; Andrew D. Hamilton

doi:10.1080/10610270600990253

Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents

Debarati M. Tagore, K. Ingrid Sprinz, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

This paper reviews the versatile self-assembly of bidentate protein-binding agents on a duplex DNA scaffold, as demonstrated using the biotin-streptavidin system. The preferential binding and stabilization of bidentate biotin-containing duplexes is reflected in a 12C increase in the melting temperature of the duplex in the presence of streptavidin.

Original language	English (US)
Pages (from-to)	129-136
Number of pages	8
Journal	Supramolecular Chemistry
Volume	19
Issue number	1-2
DOIs	https://doi.org/10.1080/10610270600990253
State	Published - Jan 2007

Keywords

Bidentate
Duplex DNA
Self-assembly

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1080/10610270600990253

Cite this

@article{4563bd9ec6684a589f0f9c253d8a7203,

title = "Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents",

abstract = "This paper reviews the versatile self-assembly of bidentate protein-binding agents on a duplex DNA scaffold, as demonstrated using the biotin-streptavidin system. The preferential binding and stabilization of bidentate biotin-containing duplexes is reflected in a 12C increase in the melting temperature of the duplex in the presence of streptavidin.",

keywords = "Bidentate, Duplex DNA, Self-assembly",

author = "Tagore, {Debarati M.} and Sprinz, {K. Ingrid} and Hamilton, {Andrew D.}",

note = "Funding Information: We thank the National Science Foundation and the National Institutes of Health (GM 35208) for financial support of this work.",

year = "2007",

month = jan,

doi = "10.1080/10610270600990253",

language = "English (US)",

volume = "19",

pages = "129--136",

journal = "Supramolecular Chemistry",

issn = "1061-0278",

publisher = "Taylor and Francis Ltd.",

number = "1-2",

}

TY - JOUR

T1 - Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents

AU - Tagore, Debarati M.

AU - Sprinz, K. Ingrid

AU - Hamilton, Andrew D.

N1 - Funding Information: We thank the National Science Foundation and the National Institutes of Health (GM 35208) for financial support of this work.

PY - 2007/1

Y1 - 2007/1

N2 - This paper reviews the versatile self-assembly of bidentate protein-binding agents on a duplex DNA scaffold, as demonstrated using the biotin-streptavidin system. The preferential binding and stabilization of bidentate biotin-containing duplexes is reflected in a 12C increase in the melting temperature of the duplex in the presence of streptavidin.

AB - This paper reviews the versatile self-assembly of bidentate protein-binding agents on a duplex DNA scaffold, as demonstrated using the biotin-streptavidin system. The preferential binding and stabilization of bidentate biotin-containing duplexes is reflected in a 12C increase in the melting temperature of the duplex in the presence of streptavidin.

KW - Bidentate

KW - Duplex DNA

KW - Self-assembly

UR - http://www.scopus.com/inward/record.url?scp=34047222690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34047222690&partnerID=8YFLogxK

U2 - 10.1080/10610270600990253

DO - 10.1080/10610270600990253

M3 - Article

AN - SCOPUS:34047222690

SN - 1061-0278

VL - 19

SP - 129

EP - 136

JO - Supramolecular Chemistry

JF - Supramolecular Chemistry

IS - 1-2

ER -

Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this