Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents

Debarati M. Tagore, K. Ingrid Sprinz, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

This paper reviews the versatile self-assembly of bidentate protein-binding agents on a duplex DNA scaffold, as demonstrated using the biotin-streptavidin system. The preferential binding and stabilization of bidentate biotin-containing duplexes is reflected in a 12C increase in the melting temperature of the duplex in the presence of streptavidin.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalSupramolecular Chemistry
Volume19
Issue number1-2
DOIs
StatePublished - Jan 2007

Keywords

  • Bidentate
  • Duplex DNA
  • Self-assembly

ASJC Scopus subject areas

  • Chemistry(all)

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