Abstract
The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work explored one possible underlying mechanism called permutation-by-duplication, which produces special forms of motif rearrangements called circular permutations. Permutation-by-duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence.
Original language | English (US) |
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Pages (from-to) | 973-978 |
Number of pages | 6 |
Journal | BioEssays |
Volume | 28 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2006 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology