Duplication, divergence and formation of novel protein topologies

Christine Vogel, Veronica Morea

Research output: Contribution to journalReview articlepeer-review


The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work explored one possible underlying mechanism called permutation-by-duplication, which produces special forms of motif rearrangements called circular permutations. Permutation-by-duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence.

Original languageEnglish (US)
Pages (from-to)973-978
Number of pages6
Issue number10
StatePublished - Oct 2006

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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