Duration of an intermittent episode of viremia

Michele Di Mascio, Jerome K. Percus, Ora E. Percus, Martin Markowitz, David D. Ho, Alan S. Perelson

Research output: Contribution to journalArticle

Abstract

HIV-1 infected patients after being treated with potent combinations of antiretroviral drugs for 2-6 months typically reach a state in which virus can no longer be detected within their blood. These patients with undetectable virus occasionally have viral load measurements that are above the limit of detection of current assays. Such measurements are called blips. Here we examine the possibility that such blips represent infrequent measurements taken during a period of time in which there is a transient elevation of virus in the patient's blood, i.e., a so-called transient episode of viremia. By analyzing time series of blips from a large number of patients, we conclude that transient episodes of viremia exist and that on average they extend for a period of about 3 weeks.

Original languageEnglish (US)
Pages (from-to)885-900
Number of pages16
JournalBulletin of Mathematical Biology
Volume67
Issue number4
DOIs
StatePublished - Jul 2005

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

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  • Cite this

    Di Mascio, M., Percus, J. K., Percus, O. E., Markowitz, M., Ho, D. D., & Perelson, A. S. (2005). Duration of an intermittent episode of viremia. Bulletin of Mathematical Biology, 67(4), 885-900. https://doi.org/10.1016/j.bulm.2004.11.003