Dynamic diffuse optical tomography for assessing changes of breast tumors during neoadjuvant chemotherapy

Jacqueline E. Gunther, Emerson Lim, Hyun Keol Kim, Mindy Brown, Susan Refice, Kevin Kalinsky, Dawn Hershman, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We have developed a dynamic diffuse optical tomography imaging system that is capable of 3D imaging of both breasts simultaneously. In an ongoing study subjects receiving neoadjuvant chemotherapy are imaged at 6 time points throughout their 5-month treatment. At each time point the subjects preform a breath hold to observe the hemodynamic effects in the breasts. For each session the percent change of various hemodynamic parameters during the breath hold is determined. Preliminary results from show statistically significant differences in washout rates and deoxyhemoglobin changes at the 2-week imaging point between subjects that respond and do not respond to treatment.

    Original languageEnglish (US)
    Title of host publicationOptical Tomography and Spectroscopy of Tissue XI
    EditorsRobert R. Alfano, Eva M. Sevick-Muraca, Bruce J. Tromberg, Arjun G. Yodh
    PublisherSPIE
    ISBN (Electronic)9781628414097
    DOIs
    StatePublished - 2015
    EventOptical Tomography and Spectroscopy of Tissue XI - San Francisco, United States
    Duration: Feb 9 2015Feb 11 2015

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume9319
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Tomography and Spectroscopy of Tissue XI
    CountryUnited States
    CitySan Francisco
    Period2/9/152/11/15

    Keywords

    • Breast imaging
    • diffuse optical tomography
    • monitoring
    • neoadjuvant chemotherapy
    • tumor response

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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