Dynamic diffuse optical tomography for monitoring neoadjuvant chemotherapy in patients with breast cancer

Jacqueline E. Gunther, Emerson A. Lim, Hyun K. Kim, Molly Flexman, Mirella Altoé, Jessica A. Campbell, Hanina Hibshoosh, Katherine D. Crew, Kevin Kalinsky, Dawn L. Hershman, Andreas H. Hielscher

Research output: Contribution to journalArticlepeer-review


Purpose: To identify dynamic optical imaging features that associate with the degree of pathologic response in patients with breast cancer during neoadjuvant chemotherapy (NAC). Materials and Of 40 patients with breast cancer who participated in a Methods: longitudinal study between June 2011 and March 2016, 34 completed the study. There were 13 patients who obtained a pathologic complete response (pCR) and 21 patients who did not obtain a pCR. Imaging data from six subjects were excluded from the study because either the patients dropped out of the study before it was finished or there was an instrumentation malfunction. Two weeks into the treatment regimen, three-dimensional images of both breasts during a breath hold were acquired by using dynamic diffuse optical tomography. Features from the breath-hold traces were used to distinguish between response groups. Receiver operating characteristic (ROC) curves and sensitivity analysis were used to determine the degree of association with 5-month treatment outcome. Results: An ROC curve analysis showed that this method could identify patients with a pCR with a positive predictive value of 70.6% (12 of 17), a negative predictive value of 94.1% (16 of 17), a sensitivity of 92.3% (12 of 13), a specificity of 76.2% (16 of 21), and an area under the ROC curve of 0.85. Conclusion: Several dynamic optical imaging features obtained within 2 weeks of NAC initiation were identified that showed statistically significant differences between patients with pCR and patients without pCR as determined 5 months after treatment initiation. If confirmed in a larger cohort prospective study, these dynamic imaging features may be used to predict treatment outcome as early as 2 weeks after treatment initiation.

Original languageEnglish (US)
Pages (from-to)778-786
Number of pages9
Issue number3
StatePublished - Jun 2018


  • Adult
  • Breast/diagnostic imaging
  • Breast Neoplasms/diagnostic imaging
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Longitudinal Studies
  • Middle Aged
  • Neoadjuvant Therapy/methods
  • Sensitivity and Specificity
  • Tomography, Optical/methods
  • Treatment Outcome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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