Dynamic diffuse optical tomography imaging of peripheral arterial disease

Michael A. Khalil, Hyun K. Kim, In Kyong Kim, Molly Flexman, Rajeev Dayal, Gautam Shrikhande, Andreas H. Hielscher

Research output: Contribution to journalArticlepeer-review


Peripheral arterial disease (PAD) is the narrowing of arteries due to plaque accumulation in the vascular walls. This leads to insufficient blood supply to the extremities and can ultimately cause cell death. Currently available methods are ineffective in diagnosing PAD in patients with calcified arteries, such as those with diabetes. In this paper we investigate the potential of dynamic diffuse optical tomography (DDOT) as an alternative way to assess PAD in the lower extremities. DDOT is a noninvasive, non-ionizing imaging modality that uses near-infrared light to create spatio-temporal maps of oxy- and deoxy-hemoglobin in tissue. We present three case studies in which we used DDOT to visualize vascular perfusion of a healthy volunteer, a PAD patient and a diabetic PAD patient with calcified arteries. These preliminary results show significant differences in DDOT time-traces and images between all three cases, underscoring the potential of DDOT as a new diagnostic tool.

Original languageEnglish (US)
Pages (from-to)2288-2298
Number of pages11
JournalBiomedical Optics Express
Issue number9
StatePublished - Sep 1 2012

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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