Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate

Hongzhou Gu, Jie Chao, Shou Jun Xiao, Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


The aim of nanotechnology is to put specific atomic and molecular species where we want them, when we want them there. Achieving such dynamic and functional control could lead to programmable chemical synthesis and nanoscale systems that are responsive to their environments. Structural DNA nanotechnology offers a powerful route to this goal by combining stable branched DNA motifs with cohesive ends to produce programmed nanomechanical devices and fixed or modified patterned lattices. Here, we demonstrate a dynamic form of patterning in which a pattern component is captured between two independently programmed DNA devices. A simple and robust error-correction protocol has been developed that yields programmed targets in all cases. This capture system can lead to dynamic control either on patterns or on programmed elements; this capability enables computation or a change of structural state as a function of information in the surroundings of the system.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalNature Nanotechnology
Issue number4
StatePublished - Apr 2009

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • General Materials Science
  • Condensed Matter Physics
  • Electrical and Electronic Engineering


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