Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis

Eli A. Stahl, Greg Dwyer, Rodney Mauricio, Martin Kreitman, Joy Bergelson

Research output: Contribution to journalArticlepeer-review


The co-evolutionary 'arms race' is a widely accepted model for the evolution of host-pathogen interactions. This model predicts that variation for disease resistance will be transient, and that host populations generally will be monomorphic at disease-resistance (R-gene) loci. However, plant populations show considerable polymorphism at R-gene loci involved in pathogen recognition. Here we have tested the arms-race model in Arabidopsis thaliana by analysing sequences flanking Rpm1, a gene conferring the ability to recognize Pseudomonas pathogens carrying AvrRpml or AvrB (ref. 3). We reject the arms-race hypothesis: resistance and susceptibility alleles at this locus have co-existed for millions of years. To account for the age of alleles and the relative levels of polymorphism within allelic dasses, we use coalescence theory to model the long-term accumulation of nucleotide polymorphism in the context of the short-term ecological dynamics of disease resistance. This analysis supports a 'trench warfare' hypothesis, in which advances and retreats of resistance-allele frequency maintain variation for disease resistance as a dynamic polymorphism.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
Issue number6745
StatePublished - Aug 12 1999

ASJC Scopus subject areas

  • General


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