Dysregulated mTORC1-dependent translational control: From brain disorders to psychoactive drugs

Emanuela Santini, Eric Klann

Research output: Contribution to journalArticle

Abstract

In the last decade, a plethora of studies utilizing pharmacological, biochemical, and genetic approaches have shown that precise translational control is required for long-lasting synaptic plasticity and the formation of long-term memory. Moreover, more recent studies indicate that alterations in translational control are a common pathophysiological feature of human neurological disorders, including developmental disorders, neuropsychiatric disorders, and neurodegenerative diseases. Finally, translational control mechanisms are susceptible to modification by psychoactive drugs. Taken together, these findings point to a central role for translational control in the regulation of synaptic function and behavior.

Original languageEnglish (US)
JournalFrontiers in Behavioral Neuroscience
Issue numberNOVEMBER
DOIs
StatePublished - Nov 2011

Keywords

  • Developmental disorders
  • Neurodegenerative diseases
  • Protein synthesis
  • Psychoactive drugs
  • S6K1
  • Translation initiation
  • eIF4E
  • mTORC1 signaling

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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