Dysregulation of mTOR signaling in fragile X syndrome

Keyphrases

• Dysregulation 100%
• Cap-dependent Translation 40%
• CA3-CA1 Synapses 40%
• Fmr1 Knockout 40%
• Predicted Targets 20%
• Target of Rapamycin Kinase 20%
• Loss Function 20%
• Genetic Causes 20%
• Transcriptional Repression 20%
• Eukaryotic Initiation Factor 20%
• Impaired Cognition 20%
• RNA-binding Protein 20%
• Downstream Targets 20%
• Link Loss 20%
• Most Common Form 20%
• Cascade Control 20%
• S6 Kinase 1 (S6K1) 20%
• Upstream Kinases 20%
• Functional Readouts 20%
• P110 20%
• 4E-binding Protein 1 20%
• Group I mGluRs 20%
• Functional Links 20%
• Overactivation 20%
• Kinase Activity 20%

Biochemistry, Genetics and Molecular Biology

• Mechanistic Target of Rapamycin 100%
• Phosphoinositide 3-Kinase 28%
• Metabotropic Receptor 28%
• Synapse 28%
• Metabotropic Glutamate Receptor 28%
• Long Term Depression 28%
• Eukaryotic Initiation Factor 14%
• Regulatory Associated Protein of mTOR 14%
• RNA-binding Protein 14%
• Esocidae 14%

Neuroscience

• Initiation Factor 4E Binding Protein 14%
• S6 Kinase 14%
• Regulatory Associated Protein of mTOR 14%
• RNA-binding Protein 14%
• Enhancer Region 14%
• Gene Product 14%