Early events associated with periodontal connective tissue attachment formation on titanium and hydroxyapatite surfaces

R. G. Craig, R. Z. LeGeros

    Research output: Contribution to journalArticlepeer-review

    Abstract

    An in vitro model was developed to characterize the effects of various biomaterial substrates on the early events of periodontal connective tissue attachment formation. Primary cultures of periodontal ligament and gingival connective tissue cells were cultured on uncoated (control) and coated (titanium- and hydroxyapatite-coated_ tissue culture plastic, and the level of cell proliferation, collagen, and noncollagen protein synthesis, alkaline phosphatase activity, and expression of a 42 kD cementum extracellular matrix protein were measured over 5, 7, and 9 days in culture. The results serve to validate the model.

    Original languageEnglish (US)
    Pages (from-to)585-594
    Number of pages10
    JournalJournal of Biomedical Materials Research
    Volume47
    Issue number4
    DOIs
    StatePublished - Dec 15 1997

    Keywords

    • Cementum
    • Collagen synthesis
    • Hydroxyapatite
    • Periodontal connective tissues
    • Titanium

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering

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