Early events associated with periodontal connective tissue attachment formation on titanium and hydroxyapatite surfaces

R. G. Craig, R. Z. LeGeros

Research output: Contribution to journalArticlepeer-review

Abstract

An in vitro model was developed to characterize the effects of various biomaterial substrates on the early events of periodontal connective tissue attachment formation. Primary cultures of periodontal ligament and gingival connective tissue cells were cultured on uncoated (control) and coated (titanium- and hydroxyapatite-coated_ tissue culture plastic, and the level of cell proliferation, collagen, and noncollagen protein synthesis, alkaline phosphatase activity, and expression of a 42 kD cementum extracellular matrix protein were measured over 5, 7, and 9 days in culture. The results serve to validate the model.

Original languageEnglish (US)
Pages (from-to)585-594
Number of pages10
JournalJournal of Biomedical Materials Research
Volume47
Issue number4
DOIs
StatePublished - Dec 15 1997

Keywords

  • Cementum
  • Collagen synthesis
  • Hydroxyapatite
  • Periodontal connective tissues
  • Titanium

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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