Early life stress is associated with greater default network deactivation during working memory in healthy controls: A preliminary report

Noah S. Philip; Lawrence H. Sweet; Audrey R. Tyrka; Lawrence H. Price; Linda L. Carpenter; Yuliya I. Kuras; Uraina S. Clark; Raymond S. Niaura

doi:10.1007/s11682-012-9216-x

Early life stress is associated with greater default network deactivation during working memory in healthy controls: A preliminary report

Noah S. Philip, Lawrence H. Sweet, Audrey R. Tyrka, Lawrence H. Price, Linda L. Carpenter, Yuliya I. Kuras, Uraina S. Clark, Raymond S. Niaura

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Early life stress (ELS) is a common risk factor for psychopathology, but there are few functional neuroimaging studies investigating its effects. In this preliminary study, we investigated the correlates of ELS exposure on the default network (DN) through measurements of task-associated DN deactivation. Data were analyzed from 19 subjects without psychiatric illness (10 with ELS). Subjects performed the working memory (WM) N-back task (including a 2-back WM and 0-back control condition) while undergoing functional MRI. We compared brain responses in the two groups across 5 bilateral DN regions using an a priori region of interest (ROI) analysis. The ELS group demonstrated significantly greater DN deactivation, observed in the right posterior cingulate cortex PCC, bilateral medial prefrontal cortex, left middle/superior frontal gyrus and right middle temporal region. These preliminary results indicate subjects with ELS demonstrate greater DN deactivations to WM challenges compared to non-ELS controls, potentially reflecting a biomarker of long-term effects of ELS exposure.

Original language	English (US)
Pages (from-to)	204-212
Number of pages	9
Journal	Brain Imaging and Behavior
Volume	7
Issue number	2
DOIs	https://doi.org/10.1007/s11682-012-9216-x
State	Published - Jun 2013

Keywords

Default network
Early life stress
Medial prefrontal cortex
Working memory
fMRI

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Cognitive Neuroscience
Clinical Neurology
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

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10.1007/s11682-012-9216-x

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title = "Early life stress is associated with greater default network deactivation during working memory in healthy controls: A preliminary report",

abstract = "Early life stress (ELS) is a common risk factor for psychopathology, but there are few functional neuroimaging studies investigating its effects. In this preliminary study, we investigated the correlates of ELS exposure on the default network (DN) through measurements of task-associated DN deactivation. Data were analyzed from 19 subjects without psychiatric illness (10 with ELS). Subjects performed the working memory (WM) N-back task (including a 2-back WM and 0-back control condition) while undergoing functional MRI. We compared brain responses in the two groups across 5 bilateral DN regions using an a priori region of interest (ROI) analysis. The ELS group demonstrated significantly greater DN deactivation, observed in the right posterior cingulate cortex PCC, bilateral medial prefrontal cortex, left middle/superior frontal gyrus and right middle temporal region. These preliminary results indicate subjects with ELS demonstrate greater DN deactivations to WM challenges compared to non-ELS controls, potentially reflecting a biomarker of long-term effects of ELS exposure.",

keywords = "Default network, Early life stress, Medial prefrontal cortex, Working memory, fMRI",

author = "Philip, {Noah S.} and Sweet, {Lawrence H.} and Tyrka, {Audrey R.} and Price, {Lawrence H.} and Carpenter, {Linda L.} and Kuras, {Yuliya I.} and Clark, {Uraina S.} and Niaura, {Raymond S.}",

note = "Funding Information: Acknowledgments Supported in part by NIH T32MH067553, R01HL084178, and P50CA084719. The authors wish to thank Denise M. Cote, M.S., for technical assistance, and Jason Hassenstab, Ph.D., for methodological assistance. This data was presented in part at the 2011 Annual Meeting of the Society of Biological Psychiatry.",

year = "2013",

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doi = "10.1007/s11682-012-9216-x",

language = "English (US)",

volume = "7",

pages = "204--212",

journal = "Brain Imaging and Behavior",

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T2 - A preliminary report

AU - Philip, Noah S.

AU - Sweet, Lawrence H.

AU - Tyrka, Audrey R.

AU - Price, Lawrence H.

AU - Carpenter, Linda L.

AU - Kuras, Yuliya I.

AU - Clark, Uraina S.

AU - Niaura, Raymond S.

N1 - Funding Information: Acknowledgments Supported in part by NIH T32MH067553, R01HL084178, and P50CA084719. The authors wish to thank Denise M. Cote, M.S., for technical assistance, and Jason Hassenstab, Ph.D., for methodological assistance. This data was presented in part at the 2011 Annual Meeting of the Society of Biological Psychiatry.

PY - 2013/6

Y1 - 2013/6

N2 - Early life stress (ELS) is a common risk factor for psychopathology, but there are few functional neuroimaging studies investigating its effects. In this preliminary study, we investigated the correlates of ELS exposure on the default network (DN) through measurements of task-associated DN deactivation. Data were analyzed from 19 subjects without psychiatric illness (10 with ELS). Subjects performed the working memory (WM) N-back task (including a 2-back WM and 0-back control condition) while undergoing functional MRI. We compared brain responses in the two groups across 5 bilateral DN regions using an a priori region of interest (ROI) analysis. The ELS group demonstrated significantly greater DN deactivation, observed in the right posterior cingulate cortex PCC, bilateral medial prefrontal cortex, left middle/superior frontal gyrus and right middle temporal region. These preliminary results indicate subjects with ELS demonstrate greater DN deactivations to WM challenges compared to non-ELS controls, potentially reflecting a biomarker of long-term effects of ELS exposure.

AB - Early life stress (ELS) is a common risk factor for psychopathology, but there are few functional neuroimaging studies investigating its effects. In this preliminary study, we investigated the correlates of ELS exposure on the default network (DN) through measurements of task-associated DN deactivation. Data were analyzed from 19 subjects without psychiatric illness (10 with ELS). Subjects performed the working memory (WM) N-back task (including a 2-back WM and 0-back control condition) while undergoing functional MRI. We compared brain responses in the two groups across 5 bilateral DN regions using an a priori region of interest (ROI) analysis. The ELS group demonstrated significantly greater DN deactivation, observed in the right posterior cingulate cortex PCC, bilateral medial prefrontal cortex, left middle/superior frontal gyrus and right middle temporal region. These preliminary results indicate subjects with ELS demonstrate greater DN deactivations to WM challenges compared to non-ELS controls, potentially reflecting a biomarker of long-term effects of ELS exposure.

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Early life stress is associated with greater default network deactivation during working memory in healthy controls: A preliminary report

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