@article{c593b224b7b645bd9135b391e6a33e2f,
title = "Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits",
abstract = "The precise connectivity of somatostatin and parvalbumin cortical interneurons is generated during development. An understanding of how these interneuron classes incorporate into cortical circuitry is incomplete but essential to elucidate the roles they play during maturation. Here, we report that somatostatin interneurons in infragranular layers receive dense but transient innervation from thalamocortical afferents during the first postnatal week. During this period, parvalbumin interneurons and pyramidal neurons within the same layers receive weaker thalamocortical inputs, yet are strongly innervated by somatostatin interneurons. Further, upon disruption of the early (but not late) somatostatin interneuron network, the synaptic maturation of thalamocortical inputs onto parvalbumin interneurons is perturbed. These results suggest that infragranular somatostatin interneurons exhibit a transient early synaptic connectivity that is essential for the establishment of thalamic feedforward inhibition mediated by parvalbumin interneurons. Tuncdemir et al. show that L5/6 SST interneurons transiently receive selective thalamocortical innervation and provide output to PV interneurons and pyramidal neurons. SST interneurons during this period are required for the synaptic maturation of PV interneurons.",
author = "Tuncdemir, {Sebnem N.} and Brie Wamsley and Stam, {Floor J.} and Fumitaka Osakada and Martyn Goulding and Callaway, {Edward M.} and Bernardo Rudy and Gord Fishell",
note = "Funding Information: We are grateful to Richard Tsien, Michael Long and members of the G.F. and B.R. labs for critical scientific discussions and comments on the manuscript. We thank Jiwon Choi for AAV-EF1α-FLEX-hGFP-B19G and Tom Jessell for AAV-Flex-DTR-GFP constructs. We thank Lihong Yin, Jiali Deng, and Jisen Dai for technical assistance. Research in the G.F. lab is supported by NIH (NS 081297, MH095147, P01NS074972) and the Simons Foundation. Research in the B.R. lab is supported by NIH (RO1NS30989, P01NS074972). Research in the E.M.C. lab is supported by NIH (EY022577, MH0639123) and the Gatsby Charitable Foundation. Research in the M.G. lab is supported by NIH (NS080586, NS086372, NS090919). Funding Information: We are grateful to Richard Tsien, Michael Long and members of the G.F. and B.R. labs for critical scientific discussions and comments on the manuscript. We thank Jiwon Choi for AAV-EF1a-FLEX-hGFP-B19G and Tom Jessell for AAV-Flex-DTR-GFP constructs. We thank Lihong Yin, Jiali Deng, and Jisen Dai for technical assistance. Research in the G.F. lab is supported by NIH (NS 081297, MH095147, P01NS074972) and the Simons Foundation. Research in the B.R. lab is supported by NIH (RO1NS30989, P01NS074972). Research in the E.M.C. lab is supported by NIH (EY022577, MH0639123) and the Gatsby Charitable Foundation. Research in the M.G. lab is supported by NIH (NS080586, NS086372, NS090919). Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
month = feb,
day = "3",
doi = "10.1016/j.neuron.2015.11.020",
language = "English (US)",
volume = "89",
pages = "521--535",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",
}