@inproceedings{dd01729335f0461c835f3540422081bc,
title = "Early treatment window for predicting breast cancer response to neoadjuvant chemotherapy in the HR+/HER2- subgroup using diffuse optical tomography",
abstract = "This work evaluates changes in features of 3D breast images generated by a so-called dynamic optical tomographic imaging system (DOTBIS) during neoadjuvant chemotherapy (NAC). Images from 23 breast cancer patients were analyzes and correlated with respect to treatment outcome and status of hormone receptors and human epidermal growth factor receptors. Our data shows that the ratio of the mean value of deoxy-hemoglobin (ctHHbN) at two weeks after the first treatment compared to baseline was statistically significantly lower in patients that achieve a pathologic complete response (pCR) (0.77 ± 0.22) as compared to patients with a non-pCR (1.14 ± 0.24, P <.005). These observations indicate that early changes in DOTBIS images can potentially be used to predict breast cancer response to NAC and may allow a better way to customize therapy to HR+/HER2- patients in order to optimize treatment.",
keywords = "Difuse optical tomography, HR+/HER2-, breast cancer, deoxy-hemoglobin, molecular subtype, neoadjuvant chemotherapy, pCR",
author = "Altoe, {Mirella L.} and Alessandro Marone and Kim, {Hyun K.} and Mariella Tejada and Hanina Hibshoosh and Hua Guo and Crew, {Katherine D.} and Accordino, {Melissa K.} and Trivedi, {Meghna S.} and Kevin Kalinsky and Hershman, {Dawn L.} and Hielscher, {Andreas H.}",
note = "Publisher Copyright: {\textcopyright} 2022 SPIE.; Multiscale Imaging and Spectroscopy III 2022 ; Conference date: 20-02-2022 Through 24-02-2022",
year = "2022",
doi = "10.1117/12.2609729",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Campagnola, {Paul J.} and Maitland, {Kristen C.} and Roblyer, {Darren M.}",
booktitle = "Multiscale Imaging and Spectroscopy III",
}