Effect of cell therapy with osteoblasts differentiated from bone marrow or adipose tissue stromal cells on bone repair

Gileade P. Freitas, Helena B. Lopes, Alann T. P Souza, Paula G.F.P. Oliveira, Adriana L. G Almeida, Paulo G. Coelho, Fernanda U. Ferreira, DImas T. Covas, Marcio M. Beloti, Adalberto L. Rosa

Research output: Contribution to journalArticle

Abstract

Aim: The aim of this study was to investigate the effect of local injection of osteoblasts differentiated from bone marrow (BM-OB) or adipose tissue (AT-OB) mesenchymal stromal cells on bone tissue formation. Materials & methods: Defects were created in rat calvaria and injected with BM-OB or AT-OB and phosphate-buffered saline without cells were injected as control. Bone formation was evaluated 4 weeks postinjection. Results: Injection of BM-OB or AT-OB resulted in higher bone formation than that obtained with control. The bone tissue induced by cell injections exhibited similar mechanical properties as those of pristine calvarial bone, and its molecular cues suggested the occurrence of a remodeling process. Conclusion: Results of this study demonstrated that cell therapy with osteoblasts induced significant bone formation that exhibited the same quality as that of pre-existent bone.

Original languageEnglish (US)
Pages (from-to)1107-1119
Number of pages13
JournalRegenerative Medicine
Volume14
Issue number12
DOIs
StatePublished - 2019

Keywords

  • adipose tissue
  • bone
  • bone marrow
  • cell therapy
  • mesenchymal stromal cell
  • osteoblast

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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